Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.

FLD may increase risk of atherosclerotic progression in healthy obese individuals

11 days ago
73% of workers aged above 40 were also found to be overweight or obese.

Despite their healthy metabolic profile, metabolically healthy obese (MHO) individuals with fatty liver disease (FLD) are at a higher risk of atherosclerotic progression, a new study shows.

The study involved 1,240 patients (mean age 54.2±7.4 years) who underwent coronary artery calcification (CAC) score measurements during routine check-ups. Those with histories of cardiovascular diseases, taking statins, with hepatocellular carcinoma and who had received liver transplants were excluded.

CAC scores were measured using coronary computed tomography angiography (CCTA) and hepatic ultrasounds. Hepatic ultrasonography was used to potentially diagnose FLD.

Of all participants, 22.7 percent (n=282) had the MHO phenotype. There were more males in the MHO group than in the MH nonobese (MHNO) group. Moreover, individuals in the MHO group had higher levels of low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG) and fasting plasma glucose (FPG).

CAC progression was observed in 25.2 percent (n=312) of participants over the median follow-up period of 2.9 (0.8 to 7.0) years. The metabolically unhealthy obese group (MUO) had the highest proportion of CAC progression (32.3 percent), followed by MHO (28.0 percent), MU nonobese (MUNO; 23.1 percent) and MHNO (19.2 percent).

MHO individuals had an increased risk of CAC progression (unadjusted odds ratio [OR], 1.63; 95 percent CI, 1.15 to 2.32) compared to MHNO individuals. After controlling for confounders, only the MUO had a significantly greater risk of CAC progression (adjusted OR, 1.71; 1.10 to 2.65).

Finally, CAC progression was significantly associated with MHO individuals with FLD at baseline (adjusted OR, 2.37; 1.34 to 4.16) relative to MHNO individuals without baseline FLD. By comparison, MHO individuals without baseline FLD showed no significant association to CAC progression (adjusted OR, 1.26; 0.71 to 2.24).

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Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.