Most Read Articles
6 days ago
Eating red meat may lead to cardiovascular (CV) target organ damage over a 4-year period, according to a recent study involving hypertensive American Indians.
6 days ago
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
Yesterday
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.

FLD may increase risk of atherosclerotic progression in healthy obese individuals

19 Apr 2017
73% of workers aged above 40 were also found to be overweight or obese.

Despite their healthy metabolic profile, metabolically healthy obese (MHO) individuals with fatty liver disease (FLD) are at a higher risk of atherosclerotic progression, a new study shows.

The study involved 1,240 patients (mean age 54.2±7.4 years) who underwent coronary artery calcification (CAC) score measurements during routine check-ups. Those with histories of cardiovascular diseases, taking statins, with hepatocellular carcinoma and who had received liver transplants were excluded.

CAC scores were measured using coronary computed tomography angiography (CCTA) and hepatic ultrasounds. Hepatic ultrasonography was used to potentially diagnose FLD.

Of all participants, 22.7 percent (n=282) had the MHO phenotype. There were more males in the MHO group than in the MH nonobese (MHNO) group. Moreover, individuals in the MHO group had higher levels of low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG) and fasting plasma glucose (FPG).

CAC progression was observed in 25.2 percent (n=312) of participants over the median follow-up period of 2.9 (0.8 to 7.0) years. The metabolically unhealthy obese group (MUO) had the highest proportion of CAC progression (32.3 percent), followed by MHO (28.0 percent), MU nonobese (MUNO; 23.1 percent) and MHNO (19.2 percent).

MHO individuals had an increased risk of CAC progression (unadjusted odds ratio [OR], 1.63; 95 percent CI, 1.15 to 2.32) compared to MHNO individuals. After controlling for confounders, only the MUO had a significantly greater risk of CAC progression (adjusted OR, 1.71; 1.10 to 2.65).

Finally, CAC progression was significantly associated with MHO individuals with FLD at baseline (adjusted OR, 2.37; 1.34 to 4.16) relative to MHNO individuals without baseline FLD. By comparison, MHO individuals without baseline FLD showed no significant association to CAC progression (adjusted OR, 1.26; 0.71 to 2.24).

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
6 days ago
Eating red meat may lead to cardiovascular (CV) target organ damage over a 4-year period, according to a recent study involving hypertensive American Indians.
6 days ago
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
Yesterday
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.