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First time blood donors face high risk of adverse events

26 Jul 2017
The shortage of blood donations has led to a black blood market in India

Young age, high haemoglobin and lower weight increase the risk of adverse events in whole blood donors, a new study has shown. Moreover, first time donors also suffer from higher risks of adverse events.

An analysis of a cohort of 18,936 adult, healthy whole blood donors showed that the overall incidence rate of adverse events was 1.1 percent (n=208). Mild adverse events comprised 0.65 percent (n=123) while severe events comprised 0.45 percent (n=85).

Incidence rate of adverse events was significantly higher in donors <30 years of age (1.5 percent; p<0.001), with haemoglobin levels >15 g/dL (1.3 percent; p=0.005) and with weight <75 kg (1.6 percent; p<0.001).

Compared with previous donors, first time donors had significantly higher incidence rate of adverse events (0.6 vs 1.6 percent; p<0.001).

Multivariate analysis revealed that age <30 years (adjusted relative risk [ARR], 1.58; 95 percent CI, 1.18 to 2.12; p=0.002), high haemoglobin levels (ARR, 1.30; 1.15 to 1.46; p<0.001) and body weight <75 kg (ARR, 1.71; 1.29 to 2.27; p<0.001) were all significant predictors of adverse events following whole blood donation.

First-time donors (ARR, 2.21; 1.64 to 2.97; p<0.001) were also at elevated risks of adverse events after adjusting for potential confounders.

Dizziness was the leading mild adverse event with an incidence rate of 84.6 percent. This was followed by pallor (75.5 percent). On the other hand, hypertension (14.4 percent) and syncope (13.0 percent) were the most frequent severe adverse events reported.

There were no significant differences in the incidence rates of mild and severe adverse events between the different significant risk predictors.

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Most Read Articles
Roshini Claire Anthony, 05 Oct 2017

Olfactory impairment in older adults may point to an elevated risk of developing Parkinson’s disease (PD), particularly in Caucasian men, a small US study found.

Elvira Manzano, Yesterday
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
07 Oct 2017
Women who follow a low-fat dietary pattern appear to have reduced breast cancer mortality, according to data from the Earlier Women’s Health Initiative Dietary Modification trial.
Pearl Toh, 5 days ago
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.