Most Read Articles
Dr. Maria Katrina Florcruz, 30 Nov 2015
Seven predominantly eczema loci possibly involved in increased risk for atopic march, two of which were previously unidentified, has been identified in a meta-analysis.
Dr. Joslyn Ngu, 07 Jan 2016

A recent study shows cefalexin is effective for treating uncomplicated cellulitis caused by streptococcal species and methicillin-susceptible Staphylococcus aureus (MSSA). [Mayo Clin Proc 2014;89(10):1436–1451]

15 Feb 2016
New drug applications approved by US FDA as of 1 - 15 Feb 2016 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
07 Sep 2016
Topical drugs with higher efficacy coefficients, as measured by minimum inhibitory concentration (MIC) in a keratin-containing media, are more effective against onychomycosis, a new study finds.

Fingernail changes may predict more serious forms of systemic sclerosis

19 Jun 2017

Fingernail changes are predictors of more severe forms of systemic sclerosis (SSc) characterized by digital microangiopathy, including digital ulcers and calcinosis cutis, according to a recent study.

Researchers conducted a case-control study involving 129 patients with SSc and 80 healthy control participants who underwent routine fingernail examination to determine the prevalence of fingernail changes in SSc and to evaluate the association between fingernail changes and other features of SSc.

Fingernail changes in SSs had a prevalence of 80.6 percent. Compared with healthy control participants, patients with SSc were more likely to have trachyonychia (p=0.006), scleronychia (p<0.0001), thickened nails (p<0.0001), brachyonychia (p=0.0004), parrot beaking (p<0.0001), pterygium inversum unguis (p<0.0001), splinter haemorrhages (p<0.0001) and cuticle abnormalities (p<0.0001).

The presence of fingernail changes showed an association with digital ulcers (p<0.0001), calcinosis cutis (p=0.004) and higher values of mean nailfold videocappillaroscopy score (p=0.0009).

“Nail changes should be systematically checked in all patients with SSc, and may be included in the American College of Rheumatology/European League Against Rheumatism classification criteria for SSc,” according to researchers.

The study was limited by its cohort that originated from a single centre.

In connective tissue diseases (CTDs), the most important site of affection is the promixal nailfold. Specifically, splinter haemorrhages (p<0.05) and capillary loops in proximal nailfold (p<0.01) in fingernails were common in patients with SSc. Fingernail changes can thus be used in combination with highly sensitive diagnostic modalities to establish an accurate diagnosis, according to a previous study that assessed the frequency and the specificity of fingernail changes associated with CTDs. [J Eur Acad Dermatol Venereol 2007;21:497-503]

Editor's Recommendations
Most Read Articles
Dr. Maria Katrina Florcruz, 30 Nov 2015
Seven predominantly eczema loci possibly involved in increased risk for atopic march, two of which were previously unidentified, has been identified in a meta-analysis.
Dr. Joslyn Ngu, 07 Jan 2016

A recent study shows cefalexin is effective for treating uncomplicated cellulitis caused by streptococcal species and methicillin-susceptible Staphylococcus aureus (MSSA). [Mayo Clin Proc 2014;89(10):1436–1451]

15 Feb 2016
New drug applications approved by US FDA as of 1 - 15 Feb 2016 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.
07 Sep 2016
Topical drugs with higher efficacy coefficients, as measured by minimum inhibitory concentration (MIC) in a keratin-containing media, are more effective against onychomycosis, a new study finds.