Most Read Articles
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.
16 Oct 2017
Elagolix is safe and effective for reducing heavy menstrual bleeding in females with fibroids, a new dose-ranging, multiple-cohort study has shown.
13 Oct 2017
Dr Joon Kiong Lee discusses pharmacotherapy for osteoporosis and the role of FLS in fracture prevention
Tristan Manalac, 06 Oct 2017
In women with polycystic ovary syndrome (PCOS), combined oral contraceptive (COC) with spironolactone is more effective than metformin in reducing symptoms while showing a similar safety profile, according to a new randomized clinical trial (RCT).

Fewer complications with LARVH than ARH for early-stage cervical cancer

08 Oct 2017

Laparoscopically assisted radical vaginal hysterectomy (LARVH) has similar survival outcomes with abdominal radical hysterectomy (ARH) for early-stage cervical cancer, but confers significantly less blood loss and shorter hospital stay, a new retrospective study has found.

The study included 77 patients, of whom 42 received ARH (median age 46.6 years) while 35 received LARVH (median age 45 years). Both groups were comparable in histological diagnosis, cancer stage, age and body mass index.

In terms of intraoperative factors, the ARG group registered significantly higher mean blood loss (861.91±349.36 vs 502.86±236.69 mL; p<0.05) and transfusion rate (54.8 vs 8.6 percent; p<0.05), with significantly more lymph nodes retrieved (36.19±12.28 vs 23.71±9.45; p<0.05), than the LARVH group.

Operative time (169.33±43.80 vs 182.74±33.98 minutes) and vaginal length (2.1±0.847 vs 2.17±0.72) were similar between the ARH and LARVH groups.

The ARH group also showed a longer mean catheterized period (10.57±4.59 vs 7.83±2.56 days; p<0.05) and hospital stay (21.41±14.94 vs 14.37±11.78 days; p<0.05) than the LARVH group.

In terms of survival outcomes, tumour recurrence was reported in 10 patients in the ARH group as opposed to three in the LARVH group, with the difference reaching statistical significance (p<0.05).

No significant difference was calculated in the other survival outcomes such as length of follow-up, disease-free survival, overall survival and mortality rate.

The current findings indicate that, despite largely similar survival outcomes, LARVH is a suitable alternative to ARH for early-stage cervical cancer because it confers fewer complications and is less invasive.

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Most Read Articles
14 Oct 2017
In pregnant women, adherence to recommended dietary intake of fat and fibre is associated with a more beneficial and richer gut microbiota which, in turn, decreases levels of the inflammation marker glycoprotein acetylation (GlycA), a study has shown.
16 Oct 2017
Elagolix is safe and effective for reducing heavy menstrual bleeding in females with fibroids, a new dose-ranging, multiple-cohort study has shown.
13 Oct 2017
Dr Joon Kiong Lee discusses pharmacotherapy for osteoporosis and the role of FLS in fracture prevention
Tristan Manalac, 06 Oct 2017
In women with polycystic ovary syndrome (PCOS), combined oral contraceptive (COC) with spironolactone is more effective than metformin in reducing symptoms while showing a similar safety profile, according to a new randomized clinical trial (RCT).