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Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
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Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 20 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Fertility therapy may increase risk of stroke

05 Sep 2017

The long-term cardiovascular (CV) safety of fertility therapy, particularly stroke, remains unclear due to the small number of studies and significant heterogeneity in this systematic review and meta-analysis.

The investigators searched published reports for studies addressing the question “does fertility therapy increase the risk of longer-term cardiovascular outcomes?” to summarize information linking fertility therapy with subsequent CV outcomes. They included 1) human studies; 2) case-control, cohort or randomized designs with 3) exposure to fertility therapy and 4) CV outcomes clearly reported; 5) presence of comparison group; 6) minimum 1-year follow-up; and 7) adjustment for age.

DerSimonian and Laird random-effects models were used to pool hazard ratios (HRs) with 95 percent confidence intervals (CIs) of outcomes such as acute cardiac event, stroke, venous thromboembolism, hypertension and diabetes mellitus, comparing women who received fertility therapy with those who did not.

A total of six observational studies were included in the meta-analysis, involving 41,910 women who received fertility therapy and 1,400,202 women who did not.

The meta-analysis showed no increased risk of a cardiac event (pooled HR, 0.91; 95 percent CI, 0.67 to 1.25; I2=36.6 percent) or diabetes mellitus (pooled HR, 0.93; 0.87 to 1.001; I2=0 percent). There were no pooled results for hypertension (I2=95.0 percent) and venous thromboembolism (I2=82.3 percent). On the other hand, a trend toward higher risk of stroke (pooled HR, 1.25; 0.96 to 1.63; I2=0 percent) was observed.

“Future studies are needed to address ongoing knowledge gaps in this area,” researchers said.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
18 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 20 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.