Females with past pre-eclampsia have higher CIMT
Carotid artery intima-media thickness (CIMT) is significantly higher in females with histories of pre-eclampsia, a recent study has found.
The study included 80 females, of which 40 had histories of pre-eclampsia (mean age at first birth 24.2±3.7 years) while the other 40 had normotensive pregnancies (mean age at first birth 24.3±3.4 years).
CIMT was significantly higher in participants with histories of pre-eclampsia than in those who have had normotensive pregnancies (median thickness 0.80 [0.75 to 0.85] vs 0.73 [0.70 to 0.78] mm; p=0.004). Hypertension (p<0.001) was significantly more common and insulin (p<0.001) was higher in those with histories of pre-eclampsia.
Ordinal logistic models showed that the likelihood of having CIMT values higher than thresholds were significantly higher in females with histories of pre-eclampsia than in normotensive participants (odds ratio [OR], 3.33; 95 percent CI, 1.50 to 7.39; p=0.003).
This statistically significant relationship remained even after adjusting for age, hypertension, dyslipidaemia, body mass index and homeostatic model assessment for insulin resistance scores (HOMA-IR; OR, 3.31; 1.32 to 8.27; p=0.01).
A subsequent meta-analysis of 10 studies showed that even at 10 years postpartum, CIMT was significantly higher in those with histories of pre-eclampsia (standardized mean difference [SMD], 0.18; 0.05 to 0.30; p=0.004).
Restricting the analysis to exclude those with chronic hypertension during pregnancy (n=5; SMD, 0.27; 0.08 to 0.46; p=0.005) or include only those above 50 years of age (SMD, 0.27; 0.05 to 0.50; p=0.02) did not attenuate the significant effect of pre-eclampsia on CIMT.