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Fat-soluble vitamin levels generally lower in IBD patients

26 Sep 2017

Patients with inflammatory bowel disease (IBD) appear to have deficiencies in fat-soluble vitamins, according to a systematic review and meta-analysis. Such deficiency highlights the need for supplementation in this population.

Researchers conducted a meta-regression analysis of 19 case-control studies evaluating the serum concentrations of fat-soluble vitamin levels in IBD patients vs healthy individuals. They identified pooled mean differences (MDs) between groups and estimated their associations with several compounding variables (age, disease duration, C-reactive protein and albumin).

Results revealed that patients with Crohn’s disease (CD) had lower levels of vitamins A (MD, 212.92 µg/L; p=0.0002), D (MD, 6.97 nmol/L; p=0.01), E (MD, 4.72 µmol/L; p=0.003) and K (MD, 1.46 ng/mL; p=0.003) compared with controls. CD patients with longer disease duration showed even lower levels of vitamins A and K (p=0.02 for both).

Similarly, patients with ulcerative colitis had lower levels of vitamin A relative to controls (MD, 223.22 µg/L; p=0.01).

Statistically significant associations were found between the levels of inflammatory biomarkers (C-reactive protein, p=0.03; albumin, p=0.0003) and vitamin A status among CD patients.

The present data highlight the need to encourage clinicians to re-evaluate the inclusion of vitamin supplementation and for further research in the field, researchers said, adding that the decreased vitamin levels often observed in IBD patients is multifactorial.

First, patients with IBD tend to avoid food due to exacerbation of the abdominal pain. Second, the presence of ulcerations or small bowel resection may reduce the intestinal absorptive surface, which can also lead to decreased vitamin levels. Finally, vitamin deficiencies may be caused by an excessive intestinal loss, effect of medical therapy or exclusive parenteral nutrition without administration of proper supplements.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.