Most Read Articles
2 years ago
Catecholamines may regulate serum HDL cholesterol level, abdominal visceral and subcutaneous fat mass in men with pheochromocytoma, based on a cross-sectional and longitudinal follow-up study.
Christina Lau, 2 years ago
The rate of intermediate- and high-risk prostate cancer, defined as a prostate-specific antigen (PSA) level greater than 10 ng/mL, has increased in the US between 2011 and 2013.
Kathlin Ambrose, 2 years ago

The most appropriate form of treatment for moderate to severe cancer pain is opioid analgesia, but less than 15 percent of Malaysian patients with cancer pain receive this treatment, says Dr Mary Cardosa, consultant anaesthetist and pain management specialist, Hospital Selayang. 

2 months ago

LY2787106, a novel fully humanized monoclonal antibody (mAb) with high affinity for hepcidin, is a well tolerated and effective therapy for regulating iron levels in cancer patients with anaemia, say US-based researchers.

Family members, caregivers must take precautions from exposure to targeted drugs

10 days ago
ETC-206 is a form of target therapy which specifically targets and inhibits Mnk enzyme in cancer cells.

There is a growing number of targeted therapies being approved for use in cancer therapy in the home setting, and this poses a potential risk among family member and caregivers, particularly those of reproductive risk age, a recent study suggests.

The findings show that most of the oral targeted therapeutics have not been tested for carcinogenicity and that the genotoxicity data are mixed. However, majority of these drugs show adverse reproductive effects, of which some are severe.

Furthermore, data that are currently available do not permit the possibility of a health hazard from inappropriate handling of drugs and contaminated patients’ waste to be ignored, especially in a long-term home setting.

There is a need for overall basic education and related precautions in order to protect family members and caregivers from indirect or direct exposure to these drugs, according to researchers, adding that further research and discussion on this subject are warranted.

In this study, researchers performed a systematic literature review and summarized the known adverse health effect of 32 oral targeted therapeutics. They particularly assessed the carcinogenicity, genotoxicity and embryo-foetal toxicity, together with the route of excretion.

“With the growing number of oral targeted therapies being approved for use in cancer therapy, the potential for long-term administration of these drugs to cancer patients is expanding,” researchers said.

“The use of these drugs in the home setting has the potential to expose family members and caregivers to them either through direct contact with the drugs or indirectly by exposure to the parent compounds and/or their active metabolites in contaminated patients’ waste,” they added.

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Most Read Articles
2 years ago
Catecholamines may regulate serum HDL cholesterol level, abdominal visceral and subcutaneous fat mass in men with pheochromocytoma, based on a cross-sectional and longitudinal follow-up study.
Christina Lau, 2 years ago
The rate of intermediate- and high-risk prostate cancer, defined as a prostate-specific antigen (PSA) level greater than 10 ng/mL, has increased in the US between 2011 and 2013.
Kathlin Ambrose, 2 years ago

The most appropriate form of treatment for moderate to severe cancer pain is opioid analgesia, but less than 15 percent of Malaysian patients with cancer pain receive this treatment, says Dr Mary Cardosa, consultant anaesthetist and pain management specialist, Hospital Selayang. 

2 months ago

LY2787106, a novel fully humanized monoclonal antibody (mAb) with high affinity for hepcidin, is a well tolerated and effective therapy for regulating iron levels in cancer patients with anaemia, say US-based researchers.