Most Read Articles
Naomi Rodrig, 2 years ago

Curing leukemia is no longer a dream, especially for leukemia types related to a single known genetic defect, argued Dr. Pia Raanani, Head of Hematology Division at the Rabin Medical Center, Petah Tikva, Israel.

Christina Lau, 2 years ago
Ultrasound screening should be routine for women with mammographically dense breasts, say researchers from Connecticut, the first US state to enact legislation mandating radiologists to inform women with dense breasts of the potential benefit of supplemental screening.
4 years ago

A radiotherapy (RT) technique that delivers much lower doses to the contralateral submandibular gland has been shown to reduce symptoms of dry month in patients with head and neck cancers.

Rajesh Kumar, 4 years ago

Older chemotherapy drugs that are no longer widely used due to their toxicity profiles are finding new uses in cancer treatment, thanks to the development of antibody-drug conjugates.

Family members, caregivers must take precautions from exposure to targeted drugs

4 days ago
ETC-206 is a form of target therapy which specifically targets and inhibits Mnk enzyme in cancer cells.

There is a growing number of targeted therapies being approved for use in cancer therapy in the home setting, and this poses a potential risk among family member and caregivers, particularly those of reproductive risk age, a recent study suggests.

The findings show that most of the oral targeted therapeutics have not been tested for carcinogenicity and that the genotoxicity data are mixed. However, majority of these drugs show adverse reproductive effects, of which some are severe.

Furthermore, data that are currently available do not permit the possibility of a health hazard from inappropriate handling of drugs and contaminated patients’ waste to be ignored, especially in a long-term home setting.

There is a need for overall basic education and related precautions in order to protect family members and caregivers from indirect or direct exposure to these drugs, according to researchers, adding that further research and discussion on this subject are warranted.

In this study, researchers performed a systematic literature review and summarized the known adverse health effect of 32 oral targeted therapeutics. They particularly assessed the carcinogenicity, genotoxicity and embryo-foetal toxicity, together with the route of excretion.

“With the growing number of oral targeted therapies being approved for use in cancer therapy, the potential for long-term administration of these drugs to cancer patients is expanding,” researchers said.

“The use of these drugs in the home setting has the potential to expose family members and caregivers to them either through direct contact with the drugs or indirectly by exposure to the parent compounds and/or their active metabolites in contaminated patients’ waste,” they added.

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Most Read Articles
Naomi Rodrig, 2 years ago

Curing leukemia is no longer a dream, especially for leukemia types related to a single known genetic defect, argued Dr. Pia Raanani, Head of Hematology Division at the Rabin Medical Center, Petah Tikva, Israel.

Christina Lau, 2 years ago
Ultrasound screening should be routine for women with mammographically dense breasts, say researchers from Connecticut, the first US state to enact legislation mandating radiologists to inform women with dense breasts of the potential benefit of supplemental screening.
4 years ago

A radiotherapy (RT) technique that delivers much lower doses to the contralateral submandibular gland has been shown to reduce symptoms of dry month in patients with head and neck cancers.

Rajesh Kumar, 4 years ago

Older chemotherapy drugs that are no longer widely used due to their toxicity profiles are finding new uses in cancer treatment, thanks to the development of antibody-drug conjugates.