Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
20 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 22 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Enzalutamide shows long-term antitumour activity in hormone-naïve prostate cancer

03 Oct 2017

Enzalutamide demonstrates antitumour activity for up to 3 years in patients with hormone-naïve prostate cancer, according to a follow-up analysis of a phase II trial. Specifically, results for bone mineral density, global health status and safety at year 3 are similar to those at year 2.

The open-label trial included 67 hormone-naïve prostate cancer patients with noncastrate testosterone (≥230 ng/dL). All patients were given enzalutamide 160 mg/day orally until disease progression or unacceptable toxicity. Prostate-specific antigen (PsA) response (≥80 percent decline from baseline) was investigated as the primary endpoint.

All patients persisted with their treatment at year 3, and 90.5 percent of the 42 patients with PsA data available during this period maintained a PsA response. Of the 26 patients with metastases at baseline, 65.4 percent showed complete or partial response as the best overall response over 3 years.

The 3-year visit data revealed marginal mean changes from baseline in total body bone mineral density or bone mineral density of the femoral neck, trochanter, spine L1 to L4 or forearm (range, -2.7 to -0.1 percent). Total body fat increased by 16.5 percent, while total lean body mass fell by -6.5 percent. There was a slight decrease in global health status from baseline.

Safety results remained favourable at 3 years. Commonly reported adverse events included gynecomastia, fatigue, hot flush and nipple pain.

An oral androgen receptor signalling inhibitor approved for treating patients with metastatic castration-resistant prostate cancer, enzalutamide acts by inhibiting the binding of androgens to the androgen receptor, androgen-receptor nuclear translocation and androgen receptor-mediated DNA binding. [N Engl J Med 2014;371:424; Lancet Oncol 2016;17:153; Science 2009;324:787]

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
20 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 22 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.