Most Read Articles
Jairia Dela Cruz, 11 Jul 2017
Nonoperative management of uncomplicated appendicitis in children entails an increased likelihood of repeat emergency department visits and hospitalizations compared with appendectomy, a retrospective study has found. Furthermore, close to half of those who receive nonoperative care require subsequent surgical removal of the appendix within the first year.
01 Jun 2013

Hypersensitivity reaction to food is becoming more common. Without a basic understanding and strict use of the various terminologies used to describe these hypersensitivity reactions, healthcare professionals face an uphill task to optimizing patient care in those who are susceptible.

Pearl Toh, 03 Jun 2016
Pure oats can be safely included in the gluten-free diet (GFD) of children with coeliac disease, concluded researchers at the recent European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) annual meeting held in Athens, Greece.
Kavitha G. Shekar, 14 Jun 2016
The incidence of type 1 diabetes mellitus (T1D) was found to be higher in juvenile idiopathic arthritis patients (JIA) compared with the general population, said German researchers at the European League Against Rheumatism Annual Congress (EULAR 2016) held in London, UK.

Endothelial dysfunction in sickle cell anaemia tied to acute chest syndrome in children

11 Sep 2017

Paediatric sickle cell anaemia (SCA) patients suffer from impaired endothelial function, a new study has found. Moreover, those with lower flow-mediated vasodilation (FMD) values have acute chest syndrome (ACS).

In a study sample of 40 paediatric SCA patients (mean age 12.3±3 years; 60 percent male), average FMD values were significantly lower than in the healthy controls (n=25; mean age 11.4±3 years; 28 percent male). Eighteen participants were on hydroxyurea treatment upon enrolment.

According to receiver operator characteristics (ROC) curve analysis, an FMD value of below 11.5 percent could distinguish SCA patients from controls with a sensitivity of 70 percent and a specificity of 80 percent. This suggests that endothelial dysfunction is a marker of SCA.

Patients with a history of ACS within the past year had significantly lower FMD values compared to those with no prior history. ROC curve analysis also showed that FMD could distinguish between those with and without prior ACS histories with an accuracy of 71 percent and a specificity of up to 79 percent. FMD also showed a significantly negative correlation with ACS (p=0.03).

The chances of having a prior ACS history were also significantly higher in paediatric SCA patients with FMD values lower than 6.65 percent (odds ratio, 1.45; 95 percent CI, 1.02 to 3.45; p=0.023).

Paediatric participants aged 6 to 18 years with haemoglobinopathy were recruited and subjected to Doppler ultrasonography to evaluate their endothelial function. Exclusion criteria included acute infection, obesity, systemic inflammation or dyslipidaemia. 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS JPOG - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Jairia Dela Cruz, 11 Jul 2017
Nonoperative management of uncomplicated appendicitis in children entails an increased likelihood of repeat emergency department visits and hospitalizations compared with appendectomy, a retrospective study has found. Furthermore, close to half of those who receive nonoperative care require subsequent surgical removal of the appendix within the first year.
01 Jun 2013

Hypersensitivity reaction to food is becoming more common. Without a basic understanding and strict use of the various terminologies used to describe these hypersensitivity reactions, healthcare professionals face an uphill task to optimizing patient care in those who are susceptible.

Pearl Toh, 03 Jun 2016
Pure oats can be safely included in the gluten-free diet (GFD) of children with coeliac disease, concluded researchers at the recent European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) annual meeting held in Athens, Greece.
Kavitha G. Shekar, 14 Jun 2016
The incidence of type 1 diabetes mellitus (T1D) was found to be higher in juvenile idiopathic arthritis patients (JIA) compared with the general population, said German researchers at the European League Against Rheumatism Annual Congress (EULAR 2016) held in London, UK.