Most Read Articles
13 Oct 2017
Higher circulating levels of docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) appear to be protective against incident atherothrombotic and cardioembolic strokes, respectively, according to a recent study.
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.

Echocardiographic phenotypes of T2DM patients show distinct clinical profiles

01 Oct 2017
The current blood glucose monitor requires a disposable test strip and a small drop of blood.

There are three different echocardiographic phenotypes of patients with type 2 diabetes mellitus (T2DM) based on cluster analysis of echocardiographic variables, according to a study. These phenotypes correlate with distinct clinical profiles and emphasize the prognostic value of left ventricular (LV) remodelling and subclinical dysfunction.

Researchers evaluated baseline echocardiography and a composite endpoint (cardiovascular mortality and hospitalization) in 842 T2DM patients from two prospective cohorts. They performed a cluster analysis on echocardiographic variables, and assessed the relationship between clusters and clinical profiles and outcomes.

A total of three clusters were identified. Patients in cluster 1 had the lowest LV mass index and ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e’) ratio, had the highest left ventricular ejection fraction (LVEF), and were predominantly male with the lowest rate of obesity or hypertension.

Those in cluster 2 had the highest strain and highest E/e’ ratio, were the oldest, were predominantly female, and had the lowest rate of isolated T2DM (without obesity or hypertension). Cluster 3 patients had the highest LV mass index and volumes and the lowest LVEF and strain, were predominantly male, and shared similar age and rate of obesity and hypertension as those in cluster 1.

The composite endpoint occurred in 56 of 521 patients (10.8 percent) after 67 months (range, 40 to 87) of follow-up. The outcome was similar between clusters 2 (hazard ratio [HR], 2.37; 95 percent CI, 1.15 to 4.88) and 3 (HR, 2.19; 1.00 to 4.82), which was worse than cluster 1.

“T2DM may alter cardiac structure and function, but obesity, hypertension or ageing can induce similar abnormalities,” researchers noted.

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Most Read Articles
13 Oct 2017
Higher circulating levels of docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) appear to be protective against incident atherothrombotic and cardioembolic strokes, respectively, according to a recent study.
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.