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Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
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Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Early colonoscopy may improve detection of bleeding source in LGIB patients

19 Apr 2017

No association exists between early colonoscopy and reduced rebleeding, length of stay (LOS) or surgery in patients with severe lower gastrointestinal bleeding (LGIB), according to a new study. However, early colonoscopy correlates with a higher rate of source localization and endoscopic intervention.

A meta-analysis was conducted on studies comparing early (<24 hours) vs delayed colonoscopy (>24 hours). Researchers accessed PubMed, Embase and Web of Science for manuscripts using colonoscopy as a diagnostic/treatment modality for patients hospitalized with LGIB. Only studies with available data on outcomes comparing early and delayed colonoscopy were included in the analysis.

The following factors were reviewed in the included articles: time to colonoscopy, rebleeding, mortality, LOS, surgery, interventions, localization of LGIB and number of packed red blood cells. The Mantel-Haenszel method was used to report pooled measures.

Of the 8,491 studies evaluated, only six were included in the meta-analysis, which involved 422 patients in the early arm and 479 in the delayed arm.

There were no between-group differences in age (64.2 vs 65.7; p=0.85), admission haemoglobin (10.3 vs 10.3 g/dL; p=0.96), LOS (5.21 vs 6.09; p=0.52) and packed red blood cells transfusion (2.37 vs 2.35; p=0.92). There was also no difference in rebleeding (odds ratio [OR], 1.38; 95 percent CI, 0.85 to 2.23), need for surgery (OR, 0.89; 0.42 to 1.89) and in hospital mortality (OR, 1.64; 0.51 to 5.32) between early and delayed colonoscopy.

On the other hand, early colonoscopy showed an association with a higher detection of bleeding source (OR, 2.97; 2.11 to 4.19) and endoscopic intervention (OR, 3.99; 2.59 to 6.13).

Early colonoscopy is recommended for LGIB patients, said researchers, adding that data regarding its association with improved outcomes is limited.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.