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Pearl Toh, 7 days ago
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Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
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Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.

Early colonoscopy may improve detection of bleeding source in LGIB patients

11 days ago

No association exists between early colonoscopy and reduced rebleeding, length of stay (LOS) or surgery in patients with severe lower gastrointestinal bleeding (LGIB), according to a new study. However, early colonoscopy correlates with a higher rate of source localization and endoscopic intervention.

A meta-analysis was conducted on studies comparing early (<24 hours) vs delayed colonoscopy (>24 hours). Researchers accessed PubMed, Embase and Web of Science for manuscripts using colonoscopy as a diagnostic/treatment modality for patients hospitalized with LGIB. Only studies with available data on outcomes comparing early and delayed colonoscopy were included in the analysis.

The following factors were reviewed in the included articles: time to colonoscopy, rebleeding, mortality, LOS, surgery, interventions, localization of LGIB and number of packed red blood cells. The Mantel-Haenszel method was used to report pooled measures.

Of the 8,491 studies evaluated, only six were included in the meta-analysis, which involved 422 patients in the early arm and 479 in the delayed arm.

There were no between-group differences in age (64.2 vs 65.7; p=0.85), admission haemoglobin (10.3 vs 10.3 g/dL; p=0.96), LOS (5.21 vs 6.09; p=0.52) and packed red blood cells transfusion (2.37 vs 2.35; p=0.92). There was also no difference in rebleeding (odds ratio [OR], 1.38; 95 percent CI, 0.85 to 2.23), need for surgery (OR, 0.89; 0.42 to 1.89) and in hospital mortality (OR, 1.64; 0.51 to 5.32) between early and delayed colonoscopy.

On the other hand, early colonoscopy showed an association with a higher detection of bleeding source (OR, 2.97; 2.11 to 4.19) and endoscopic intervention (OR, 3.99; 2.59 to 6.13).

Early colonoscopy is recommended for LGIB patients, said researchers, adding that data regarding its association with improved outcomes is limited.

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Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.