Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS. 
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Dutasteride does not increase CV risk relative to finasteride

2 months ago

It appears that dutasteride does not elevate the risk of cardiovascular (CV) events in relation to finasteride, suggest the results of a recent population-based cohort study.

To investigate the risk of CV events among patients receiving dutasteride (n=36,311) compared with finasteride (n=36,311), researchers analysed Ontario men (≥66 years) who commenced treatment with dutasteride or finasteride between 1 October 2005 and 31 March 2015. Participants were matched 1:1 based on a propensity score and calendar quarter of treatment initiation to account for temporal changes in prescribing.

Hospitalization for heart failure was the primary outcome. Secondary analyses were performed to examine acute myocardial infarction and stroke. To adjust for differences between groups, researchers used Cox proportional hazards regression.

Primary analysis showed no difference in the risk of heart failure among patients receiving dutasteride relative to those receiving finasteride (adjusted hazard ratio [HR], 0.98; 95 percent CI, 0.88 to 1.08). Similarly, there was no difference observed in the risk of acute myocardial infarction (HR, 0.94; 0.82 to 1.08) or stroke (HR, 1.03; 0.88 to 1.20).

A study by Cindolo and colleagues in 2013 suggested that the clinical effects of dutasteride and finasteride might be different. Patients treated with dutasteride appeared to be less likely to have benign prostatic hyperplasia-related hospitalization. [World J Urol 2013;31:665-71; Arch Ital Urol Androl 2013;85:200-6]

In another study, a retrospective analysis of data from consecutive patients treated at a single clinic found that both finasteride and dutasteride were effective for the management of lower urinary tract symptoms. However, dutasteride had significantly more sexual side effects and breast complications than finasteride. [Int J Clin Pract 2012;66:1052-5]

Dutasteride inhibits both type 1 and type 2 isoforms of 5α-reductase, while finasteride selectively inhibits the type 2 isoform, according to researchers.

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Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS. 
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.