Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

DS-8500a improves glycaemic, lipid variables in T2D

Audrey Abella
26 Sep 2017

The novel, G-protein coupled receptor 119 (GPR119) agonist DS-8500a demonstrated dose-dependent glucose-lowering effects and favourable improvements in lipid parameters that extended up to 12 weeks in Japanese patients with type 2 diabetes mellitus (T2D), according to data presented at EASD 2017.

This multicentre, double-blind trial comprised 368 patients with T2D and HbA1c levels between ≥7 and <10 percent. Participants were randomized 1:1:1 to receive once-daily administration of DS-8500a (either 25 mg, 50 mg, or 75 mg), sitagliptin 50 mg, or placebo for 12 weeks. [EASD 2017, abstract 847]

At week 12, a dose-dependent reduction in HbA1c levels was observed among patients on DS-8500a compared with placebo (-0.21 percent; p=0.0233 for 25 mg, -0.34 percent; p=0.0004 for 50 mg, and -0.45 percent; p<0.0001 for 75 mg).

Compared with placebo, DS-8500a 50 mg and 75 mg also reduced fasting plasma glucose (FPG, -12.7 mg/dL; p=0.0004 and -14.4 mg/dL; p<0.0001, respectively), area under the curve0-3h for glucose during a meal tolerance test (-50.6 mg/dL x h; p=0.0020 and -59.7 mg/dL x h; p=0.0003), and 2-hour postprandial glucose (-18.5 mg/dL; p=0.0102 and -22.0 mg/dL; p=0.0022).

FPG reduction was sustained for up to 12 weeks, said the researchers, which is an improvement from other GPR119 agonists that typically have shorter glucose-lowering effects lasting for up to 2–4 weeks only.

With regards to lipid profile, administration of DS-8500a 50 mg and 75 mg resulted in a significant increase in HDL cholesterol vs placebo (5.9 percent; p=0.0032 and 6.6 percent; p=0.0009, respectively), as well as a significant reduction in total cholesterol (-7.0 percent; p<0.0001 and -6.2 percent; p=0.0002), LDL cholesterol (-7.3 percent; p=0.0044 and -8.1 percent; p=0.0014), and triglycerides (-32.7 percent; p<0.0001 and -30.9 percent; p<0.0001).

Apart from two cases of clinically-relevant drug-related hypoglycaemia in the DS-8500a 50 mg arm, DS-8500a was generally well tolerated with no reports of serious drug-related treatment-emergent adverse events at any dose of DS-8500a.

These results were consistent with the findings of a previous study in another Japanese cohort, [Diabetes 2016;65:abstract 119-LB] providing additional data showing the potential benefit of DS-8500a for T2D, noted the researchers.

 

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.