Most Read Articles
17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

01 Dec 2015
Canagliflozin reduces glycaemic parameters and body weight in type 2 diabetes mellitus (T2DM) patients, based on a systematic review and meta-analysis.

Dragon fruit reduces FPG in patients with prediabetes but not type 2 diabetes

11 Sep 2017
Those with type 2 diabetes can reduce their risk of complications with tight control of their blood sugar and blood pressure levels

Dragon fruit appears to significantly reduce fasting plasma glucose (FPG) in individuals with prediabetes, according to a recent meta-analysis. In contrast, dragon fruit exerts no beneficial effect on type 2 diabetes patients.

The current meta-analysis involved four studies, of which three were nonblinded parallel studies that focused on type 2 diabetes patients, while one was a single-blinded cross-over study that examined individuals with prediabetes.

The study that looked at individuals with prediabetes included three treatment arms each with their own controls; each arm was considered a separate study. Pooled data from these arms showed that dragon fruit significantly decreased FPG levels compared with controls (mean difference [MD], -15.1 mg/dL; 95 percent CI, -23.8 to -6.5 mg/dL; p=0.0006).

In contrast, data from the three studies that focused on type 2 diabetes patients showed that, while FPG was decreased in the dragon fruit group, the difference did not reach statistical significance (MD, -26.5 mg/dL; -72.6 to 19.6 mg/dL; p=0.26).

Similarly, dragon fruit also does not exert a significant impact on 2 hours postprandial glucose (2HPP) levels (MD, -30.5 mg/dL; -80.9 to 19.9 mg/dL; p=0.24).

Randomized controlled trials that compared the effect of dragon fruit on the glycaemic control of patients with prediabetes or type 2 diabetes against placebo were searched from the databases of Medline, Web of Science and the Cochrane Central Register of Controlled Trials, among others.

“The effect in [type 2 diabetes] was not significant, but there was a trend towards greater blood glucose reduction with higher dose. Due to restricted available data and poor quality of clinical evidence, larger, adequate-power, well-controlled clinical trials are required to further evaluate the clinical benefit of dragon fruit in these patients,” said researchers.

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Most Read Articles
17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.
Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

01 Dec 2015
Canagliflozin reduces glycaemic parameters and body weight in type 2 diabetes mellitus (T2DM) patients, based on a systematic review and meta-analysis.