Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
2 years ago
A study on participants from the Women's Health Initiative showed the dissociation between calcium/vitamin D supplementation and reduction in menopausal symptoms.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS. 

Dekavil shows initial signs of safety and efficacy in rheumatoid arthritis

Jackey Suen
one month ago

The fully-human immunocytokine dekavil (also known as F8-IL10) has demonstrated signs of safety and efficacy in patients with active rheumatoid arthritis (RA) in a phase I study presented at the European League Against Rheumatism (EULAR) Annual Congress 2017.

 “A total of 35 patients were enrolled in the study. They had a median age of 63 years, median disease duration of 17.5 years, and median Disease Activity Score in 28 joints [DAS 28 score] of 5.75,” said co-investigator Professor Mauro Galeazzi of the University Hospital Siena, Italy. “All patients had received prior treatment with methotrexate and at least one anti-tumour necrosis factor [anti-TNF] therapy. Most of them had also received steroids previously.” [EULAR 2017, abstract OP0099]

In this phase Ib dose escalation study, patients with active RA received four weekly subcutaneous injections of dekavil 6–600 µg/kg plus methotrexate. They were given an option to receive an additional 4 weeks of treatment. [https://clinicaltrials.gov/ct2/show/NCT02076659]

“Overall, dekavil was well tolerated up to the highest investigated dose of 600 µg/kg,” reported Galeazzi. “Mild injection site reactions occurred in 60 percent of the patients. Two patients had treatment-related anaemia [grade 2 and grade 3, respectively]. One patient experienced dose-limiting grade 2 purpura.”

“At the first efficacy assessment after 4 weeks of treatment, 60 percent of the patients demonstrated responses according to the American College of Rheumatology [ACR] criteria and/or EULAR criteria. The response rate improved to 62.5 percent after 8 weeks of treatment,” he continued. “Notably, two patients achieved 70 percent improvement according to the ACR criteria [ACR70], and the responses were maintained for more than 1 year after the end of treatment. These patients received dekavil 30 µg/kg and 60 µg/kg, respectively, during the study period.”

In view of the good tolerability and promising signs of efficacy of dekavil as shown in the current study, the investigators have initiated a randomized, double-blind, multicentre, placebo-controlled phase II study to further evaluate the safety and efficacy of dekavil 30 µg/kg and 160 µg/kg in combination with methotrexate in patients with active RA. [https://clinicaltrials.gov/ct2/show/NCT02270632]

“Chronic inflammatory and autoimmune conditions such as RA can cause severe pain and affect patient’s quality of life. However, currently available medical treatments for the disease help only a subset of patients,” noted Geleazzi. “Immunocytokines are antibody–cytokine fusion proteins that allow for selective induction of immunologic tolerance at the site of inflammation while sparing healthy tissue. They represent a novel class of drugs for the treatment of chronic inflammation and autoimmune conditions.” [Drug Discov Today 2016;21:180-189]

Dekavil is a fully-human immunocytokine comprising F8 antibody, which brings the fusion protein to synovial tissue by binding selectively to oncofaetal fibronectin, and interleukin-10, which exhibits immunosuppressive effects. The drug was previously shown to stabilize RA in a mouse model. [Arthritis Res Ther 2009;11:R142]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacy - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

one year ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
2 years ago
A study on participants from the Women's Health Initiative showed the dissociation between calcium/vitamin D supplementation and reduction in menopausal symptoms.
Elvira Manzano, one year ago
The oral Janus kinase (JAK) inhibitor tofacitinib may be a promising therapeutic option for patients with ankylosing spondylitis (AS), according to an expert who presented results from a phase II study that was touted as the first to demonstrate the efficacy of a JAK inhibitor in AS.