Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
08 Oct 2017
Treatment with vismodegib does not appear to increase the risk of subsequent squamous cell carcinoma (SCC) in comparison with standard surgical treatment of basal cell carcinoma (BCC), a recent study suggests.
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Death, recurrence in NSCLC not tied to opioid usage

29 Jul 2017
More than 33,000 have died in America from opioid overdose in 2015 alone.

Opioid usage is not associated with long-term outcomes such as death and risk of recurrence in non-small cell lung cancer (NSCLC) patients, a new study has found.

The study included 871 NSCLC patients stratified into quartiles according to opioid use. Only patients who underwent sleeve lobectomy, bilobectomy or lobectomy were included. Exclusion criteria included death, need for revision surgery, occurrence of a different primary cancer within 5 years and incomplete medical records.

Multivariate logistic regression models showed that opioid dosage was not associated with either recurrence (Wald chi-square, 0.4128; p=0.520) or death (Wald chi square, 0.1939; p=0.659). However, when taking cancer stage into account, opioid use was significantly correlated with recurrence (p=0.004) and death (p=0.049).

A 1-unit increase in opioid dosage was correlated with a significant increase in recurrence for cancer stages IA (odds ratio [OR], 1.001; 95 percent CI, 1.001 to 1.001; p=0.004), IB (OR, 1.001; 1.000 to 1.001; p=0.02) and IB (OR, 1.001; 1.001 to 1.002; p=0.0006).

Similar significant increases in the risk of death in cancer stages IA (OR, 1.001; 1.000 to 1.001; p=0.0105), IB (OR, 1.001; 1.000 to 1.001; p=0.0317) and IIB (OR, 1.001; 1.000 to 1.001; p=0.0363) were calculated with a 1-unit increase in opioid dosage.

However, because of the small magnitude of the ORs, it may be concluded that opioid usage does not affect risk of death or recurrence in NSCLC regardless of stage, researchers said.

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Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
08 Oct 2017
Treatment with vismodegib does not appear to increase the risk of subsequent squamous cell carcinoma (SCC) in comparison with standard surgical treatment of basal cell carcinoma (BCC), a recent study suggests.
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.