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Dairy product intake may increase incidence of hip arthroplasty for OA in men

01 Aug 2017

Increasing consumption of dairy products may heighten the risk of total hip arthroplasty for men with osteoarthritis (OA), according to a study, adding that such an association is not seen in women.

In this prospective cohort study that sought to determine whether dairy product consumption was associated with the incidence of total hip arthroplasty for OA, researchers enrolled 38,924 participants who had dairy product intake recorded from 1990 to 1994.

The authors determined the incidence of total hip arthroplasty for OA during 2001 to 2013 by linking cohort records to the Australian Orthopaedic Association National Joint Replacement Registry.

There were 1,505 total hip arthroplasties for OA (524 in men and 981 in women) over an average follow-up of 11.8 years. A 1 SD increase in dairy product consumption was associated with a 21-percent rise in incidence of total hip arthroplasty for OA in men (hazard ratio [HR], 1.21; 95 percent CI, 1.10 to 1.33), with a dose-response relationship seen for quartiles of dairy product intake (p=0.001 for trend).

This association was independent of age, body mass index, country of birth, education, smoking status, vigorous physical activity, energy consumption, calcium supplementation, diabetes, hypertension and circulating 25-hydroxy vitamin D.

There was no significant association observed for women (HR, 1.02; 0.95 to 1.09), according to researchers, adding that understanding the mechanisms may help develop strategies to prevent hip OA, particularly for men.

In an earlier study, researchers found an association between increasing concentrations of serum 25-hydroxy vitamin D and an elevated risk of hip arthroplasty for OA in men, whereas no significant association was found in women. [Osteoarthritis Cartilage 2015;23:2134-40]

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
18 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 20 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.