Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.

Daily regorafenib better tolerated than intermittent dosing in GIST

10 Sep 2017

Regorafenib at 120 mg daily is the preferred dosing pattern for gastrointestinal stromal tumour (GIST) compared to the standard intermittent dosing and yields comparable efficacy with better tolerability, a new study shows.

The study included 28 GIST patients (mean age at therapy 58±14.7 years; 60.7 percent male) who received regorafenib at a 120 mg continuous daily dosing schedule (79 percent; n=22) or at the standard intermittent dosing schedule (21 percent; n=6).

The Choi and Response Evaluation Criteria in Solid Tumours (RECIST) criteria were used to determine tumour response to treatment. Kaplan-Meier analysis was performed to determine overall survival (OS) and progression-free survival (PFS).

Over a median follow-up period of 26.8 months, 19 patients (n=68 percent) died. The median OS period after therapy initiation was 18.3 months. The median PFS after initiation of therapy was 9.4 months, and 89 percent (n=28) of the patients either died or progressed.

Stable disease was reported in 32 percent of the patients, and the treatment response rate was 39 percent.

In the RECIST criteria, the best overall response rate (ORR) was 4 percent (n=1) with a recorded time to response of 4 months. At the first follow-up 2 months after treatment initiation, the response rate was 0 percent. Disease control rate (DCR) was 71.4 percent (n=20).

In the Choi criteria, best ORR and DCR was 29 percent (n=8) and 71.4 percent (n=20), respectively. In both criteria, none of the responses recorded were complete responses.

Any-grade adverse events (AE) were reported in 93 percent (n=26) of the patients, while grade 3/4 AEs were reported in 43 percent (n=12). The most common any-grade AE was hand-foot syndrome, observed in 61 percent of patients. This was followed by fatigue (50 percent) and weight loss (43 percent).

Half of those on the intermittent dosing schedule discontinued therapy because of AEs, while only 14 percent in the continuous dosing group discontinued.

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Most Read Articles
5 days ago
There appears to be an association between waterpipe tobacco smoking and gastro-oesophageal reflux disease (GERD), which is a known risk factor for oesophageal adenocarcinoma, a study has shown.
Tristan Manalac, 6 days ago
An 8-week regimen of sofosbuvir-velpatasvir-voxilaprevir combination is not noninferior to a 12-week regimen of sofosbuvir-velpatasvir for patients with chronic hepatitis C virus (HCV) infection, report two recent phase 3 open-label trials.
2 days ago
The additional use of intermittent low-energy diet (LED) or daily meal replacements after a mean 10-percent weight loss and 1-year maintenance effectively maintains weight loss in obese patients with knee osteoarthritis for 3 years, according to a recent study.
5 days ago
A recent study has found that food bolus impaction or strictures predict most episodes of oesophageal perforation, a rare but serious complication of eosinophilic esophagitis (EoE) that occurs in about 2 percent of cases. This suggests that patients with fibrostenotic disease due to longer duration of symptoms are at increased risk.