Most Read Articles
01 Jul 2013

Acne is particularly prevalent during adolescence, and some teenagers will face an on-going battle with this common skin condition.

01 Apr 2013

Preventing acne and treating oily and acne-prone skin is all about getting back to basics when it comes to products and face-washing routines, a New Zealand pharmacist says.

01 Jul 2013

Acne is a ‘pain,’ as many will attest. It may not be life-threatening, but its impact on quality of life can be great. For the many people who have had to put up with it for a long time, there is frustration and embarrassment, and even anger and depression. Nevertheless, there is hope.

01 Aug 2013

Acne vulgaris (common acne) is the most common skin disease. It is a chronic condition in which there is a blockage or inflammation of hair follicles and the accompanying sebaceous glands.

CXCL-9, CXCL-10, CXCL-10, IFN-γ elevated in adult-onset Still’s disease

16 May 2017

Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.

The study included 39 patients with untreated AOSD, 30 with rheumatoid arthritis (RA) and 28 healthy controls. Those with autoimmune, neoplastic and infectious disorders were excluded. Baseline demographic information, clinical characteristics, AOSD activity and laboratory findings were recorded.

Enzyme-linked immunosorbent assays (ELISA) were used to measure serum levels of CXCL-11, CXCL-9, CXCL-10, IFN-β, IFN-α and IFN-γ. Skin biopsies from 34 AOSD patients were subjected to histopathological analysis to determine disease activity.

Among the three groups, there were no significant differences in gender or age. The most common symptoms of AOSD were high spiking fevers (94.9 percent) followed by skin rashes (87.2 percent), arthritis (53.8 percent), sore throat (56.4 percent) and splenomegaly (20.5 percent). At baseline, all AOSD patients had high levels of disease activity.

AOSD patients had significantly higher levels of IFN-γ (50.5±34.4 pg/mL) compared with RA patients (27.7±21.4 pg/mL; p=0.001) and healthy controls (23.7±11.1 pg/mL; p<0.001). Similarly, CXCL-9 (595.6±790.8 pg/mL) and CXCL-10 (229.5±188.1 pg/mL) levels were significantly higher in AOSD patients than in RA patients (p<0.001 for both) and healthy controls (p<0.001 for both).

Further analysis showed that levels of CXCL-9 (p=0.004), CXCL-10 (p=0.003) and CXCL-11 (p=0.017) were significantly greater in AOSD patients with reactive haemophagocytic syndrome (RHS) than those without. IFN-γ levels were not significantly different between the two groups.

Finally, in follow-up samples collected 8.1±6 months after initial collections, mean levels of CXCL-9, CXCL-10 and CXCL-11 decreased significantly compared with initial samples. The level of IFN-γ did not change significantly.

Editor's Recommendations
Most Read Articles
01 Jul 2013

Acne is particularly prevalent during adolescence, and some teenagers will face an on-going battle with this common skin condition.

01 Apr 2013

Preventing acne and treating oily and acne-prone skin is all about getting back to basics when it comes to products and face-washing routines, a New Zealand pharmacist says.

01 Jul 2013

Acne is a ‘pain,’ as many will attest. It may not be life-threatening, but its impact on quality of life can be great. For the many people who have had to put up with it for a long time, there is frustration and embarrassment, and even anger and depression. Nevertheless, there is hope.

01 Aug 2013

Acne vulgaris (common acne) is the most common skin disease. It is a chronic condition in which there is a blockage or inflammation of hair follicles and the accompanying sebaceous glands.