Most Read Articles
one month ago
Quality-of-life (QoL) improvements in patients with psoriasis are faster and greater with secukinumab than etanercept treatment, according to a recent study.
4 months ago
Patients with hidradenitis suppurativa (HS) have four to eight times higher prevalence (3.3 percent) of inflammatory bowel disease (IBD; Crohn’s disease or ulcerative colitis) than the general northern European population (0.41 to 0.74 percent), results of a multicentre, cross-sectional study have found.
Tristan Manalac, one month ago
The fractional radiofrequency technique (fRF) reduces post-inflammatory hyperpigmentation (PIH) in treating atrophic acne scars in Asians compared with fractional laser methods, reports a review manuscript accepted for publishing in the Journal of Cosmetic and Laser Therapy.
Stephen Padilla, 12 days ago
The use of topical ruxolitinib 1.5% cream, a Janus kinase (JAK) inhibitor, delivers significant repigmentation in facial vitiligo, promising a new treatment for the said skin disease, reports a recent study.

CXCL-9, CXCL-10, CXCL-10, IFN-γ elevated in adult-onset Still’s disease

12 days ago

Increased serum levels of C-X-C motif chemokine (CXCL)-11, CXCL-9, CXCL-10 and interferon (IFN)-γ are associated with clinical manifestations of adult-onset Still’s disease (AOSD), reports a new study.

The study included 39 patients with untreated AOSD, 30 with rheumatoid arthritis (RA) and 28 healthy controls. Those with autoimmune, neoplastic and infectious disorders were excluded. Baseline demographic information, clinical characteristics, AOSD activity and laboratory findings were recorded.

Enzyme-linked immunosorbent assays (ELISA) were used to measure serum levels of CXCL-11, CXCL-9, CXCL-10, IFN-β, IFN-α and IFN-γ. Skin biopsies from 34 AOSD patients were subjected to histopathological analysis to determine disease activity.

Among the three groups, there were no significant differences in gender or age. The most common symptoms of AOSD were high spiking fevers (94.9 percent) followed by skin rashes (87.2 percent), arthritis (53.8 percent), sore throat (56.4 percent) and splenomegaly (20.5 percent). At baseline, all AOSD patients had high levels of disease activity.

AOSD patients had significantly higher levels of IFN-γ (50.5±34.4 pg/mL) compared with RA patients (27.7±21.4 pg/mL; p=0.001) and healthy controls (23.7±11.1 pg/mL; p<0.001). Similarly, CXCL-9 (595.6±790.8 pg/mL) and CXCL-10 (229.5±188.1 pg/mL) levels were significantly higher in AOSD patients than in RA patients (p<0.001 for both) and healthy controls (p<0.001 for both).

Further analysis showed that levels of CXCL-9 (p=0.004), CXCL-10 (p=0.003) and CXCL-11 (p=0.017) were significantly greater in AOSD patients with reactive haemophagocytic syndrome (RHS) than those without. IFN-γ levels were not significantly different between the two groups.

Finally, in follow-up samples collected 8.1±6 months after initial collections, mean levels of CXCL-9, CXCL-10 and CXCL-11 decreased significantly compared with initial samples. The level of IFN-γ did not change significantly.

Editor's Recommendations
Most Read Articles
one month ago
Quality-of-life (QoL) improvements in patients with psoriasis are faster and greater with secukinumab than etanercept treatment, according to a recent study.
4 months ago
Patients with hidradenitis suppurativa (HS) have four to eight times higher prevalence (3.3 percent) of inflammatory bowel disease (IBD; Crohn’s disease or ulcerative colitis) than the general northern European population (0.41 to 0.74 percent), results of a multicentre, cross-sectional study have found.
Tristan Manalac, one month ago
The fractional radiofrequency technique (fRF) reduces post-inflammatory hyperpigmentation (PIH) in treating atrophic acne scars in Asians compared with fractional laser methods, reports a review manuscript accepted for publishing in the Journal of Cosmetic and Laser Therapy.
Stephen Padilla, 12 days ago
The use of topical ruxolitinib 1.5% cream, a Janus kinase (JAK) inhibitor, delivers significant repigmentation in facial vitiligo, promising a new treatment for the said skin disease, reports a recent study.