Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.

CVD risk higher in systemic lupus, psoriasis and rheumatoid arthritis

02 Aug 2017

The prevalence of cardiovascular diseases (CVDs) is higher in rheumatoid arthritis, psoriasis and systemic lupus erythematosus than in other immune-mediated inflammatory diseases (IMIDs), a new cross-sectional analysis has shown.

The analysis of six cohorts (n=9,951) showed that, using the rheumatoid arthritis cohort as a reference, CVD risk was moderately lower in the psoriasis (odds ratio [OR], 0.89; 95 percent CI, 0.66 to 1.19; p=0.42) and systemic lupus erythematosus (OR, 0.74; 0.47 to 1.17; p=0.19) cohorts before adjustments.

In contrast, the risk of CVD was significantly lower in the ulcerative colitis (OR, 0.35; 0.22 to 0.56; p<0.001), Crohn’s disease (OR, 0.16; 0.09 to 0.29; p<0.001) and psoriatic arthritis (OR, 0.48; 0.31 to 0.76; p=0.002) cohorts compared to the rheumatoid arthritis cohort before adjustments.

After adjusting for demographic variables, educational level and traditional CV risk factors, multivariable models showed that the psoriasis (OR, 0.67; 0.42 to 1.05; p=0.078) and Crohn’s disease (OR, 0.50; 0.23 to 1.09; p=0.083) cohorts had nonsignificantly lower risks of CVD compared with the rheumatoid arthritis cohort.

The risk of CVD was significantly lower in the psoriatic arthritis (OR, 0.46; 0.23 to 0.92; p=0.028) and ulcerative colitis (OR, 0.35; 0.16 to 0.75; p=0.007) cohorts. In contrast, the risk of CVD was significantly higher in the systemic lupus erythematosus vs the rheumatoid arthritis cohort (OR, 3.64; 1.93 to 6.85; p<0.001) in multivariate analysis.

Any diagnosis of myocardial infarction, stroke, peripheral vascular disease or angina after identification of IMIDs was defined as the presence of CVD and was designated as the dependent outcome.

Of the 9,951 participants, 2,152 had rheumatoid arthritis, 1,147 had psoriatic arthritis, 2,497 had psoriasis, 760 had systemic lupus erythematosus, 1,938 had Crohn’s disease and 1,457 had ulcerative colitis.

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Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.