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CVD risk higher in systemic lupus, psoriasis and rheumatoid arthritis

02 Aug 2017

The prevalence of cardiovascular diseases (CVDs) is higher in rheumatoid arthritis, psoriasis and systemic lupus erythematosus than in other immune-mediated inflammatory diseases (IMIDs), a new cross-sectional analysis has shown.

The analysis of six cohorts (n=9,951) showed that, using the rheumatoid arthritis cohort as a reference, CVD risk was moderately lower in the psoriasis (odds ratio [OR], 0.89; 95 percent CI, 0.66 to 1.19; p=0.42) and systemic lupus erythematosus (OR, 0.74; 0.47 to 1.17; p=0.19) cohorts before adjustments.

In contrast, the risk of CVD was significantly lower in the ulcerative colitis (OR, 0.35; 0.22 to 0.56; p<0.001), Crohn’s disease (OR, 0.16; 0.09 to 0.29; p<0.001) and psoriatic arthritis (OR, 0.48; 0.31 to 0.76; p=0.002) cohorts compared to the rheumatoid arthritis cohort before adjustments.

After adjusting for demographic variables, educational level and traditional CV risk factors, multivariable models showed that the psoriasis (OR, 0.67; 0.42 to 1.05; p=0.078) and Crohn’s disease (OR, 0.50; 0.23 to 1.09; p=0.083) cohorts had nonsignificantly lower risks of CVD compared with the rheumatoid arthritis cohort.

The risk of CVD was significantly lower in the psoriatic arthritis (OR, 0.46; 0.23 to 0.92; p=0.028) and ulcerative colitis (OR, 0.35; 0.16 to 0.75; p=0.007) cohorts. In contrast, the risk of CVD was significantly higher in the systemic lupus erythematosus vs the rheumatoid arthritis cohort (OR, 3.64; 1.93 to 6.85; p<0.001) in multivariate analysis.

Any diagnosis of myocardial infarction, stroke, peripheral vascular disease or angina after identification of IMIDs was defined as the presence of CVD and was designated as the dependent outcome.

Of the 9,951 participants, 2,152 had rheumatoid arthritis, 1,147 had psoriatic arthritis, 2,497 had psoriasis, 760 had systemic lupus erythematosus, 1,938 had Crohn’s disease and 1,457 had ulcerative colitis.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.