Most Read Articles
Pearl Toh, 08 Jun 2016
Middle East Respiratory Syndrome (MERS) patients have more severe illness and a higher mortality rate than non-MERS severe acute respiratory infection (SARI) patients, according to a study presented at the recent American Thoracic Society (ATS) International Conference 2016 held in San Francisco, California, US.
17 Jul 2017
There appears to be no evidence supporting associations between physical activity and asthma control level, spirometric measurements and quality of life in children and adolescents with asthma, according to a study from Brazil.
01 Feb 2016
Ampicillin/sulbactam is an effective first-line therapy among elderly patients with Nursing- and Healthcare- associated Pneumonia (NHCAP), as observed in a retrospective analysis.
Radha Chitale, 17 May 2016
Advanced non-small cell lung cancer (NSCLC) patients with uncommon mutations did not respond as well to first generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as those with more common mutations, according to a small, retrospective Japanese study presented at the IASLC Asia Pacific Lung Conference (APLCC) 2016, held recently in Chiang Mai, Thailand.

CRP, ferritin levels may distinguish patients with positive sputum cultures 60 days after ATT

15 Apr 2017
Reduce TB prevalence to 10 per 100,000 by 2022

Circulating levels of C-reactive protein (CRP) and ferritin are elevated in patients with tuberculosis (TB) starting antituberculosis therapy (ATT) and decrease over time, a new study shows. However, those that still had positive cultures after 60 days of ATT show elevated levels of these markers.

The longitudinal cohort study involved 165 pulmonary (75.7 percent male; median age 40 years) TB patients initiating ATT and between the ages of 18 and 60. Those who were taking antituberculosis medication, had type 1 diabetes mellitus, renal failure, were receiving peritoneal or haemodialysis, and pregnant were excluded.

Cryopreserved serum samples were used to measure serum levels of CRP and ferritin. Sputum samples were also collected from participants and were assessed for the respective mycobacterial loads. The associations between these parameters and sputum conversion at 60 days after ATT were evaluated.

Among all the comorbidities, anaemia (75 percent), HIV/AIDS (10 percent), type 2 diabetes (3 percent) and chronic obstructive pulmonary disease (3 percent) were the most common. Active smoking, chronic alcoholism and illicit drug use were reported in 73, 59.4 and 28.5 percent, respectively, of the study population.

Prospective analysis showed a drop in CRP levels from day 0 to day 30 of ATT (p<0.001); this trend continued to day 60 but was not significant. Levels of ferritin at day 60 was significantly reduced compared to its levels at day 0 (p<0.001) and day 30 (p<0.05). Ferritin and CRP were significantly correlated at pretreatment (p<0.0001), day 30 (p=0.001) and day 60 (p<0.0001).

Patients with negative sputum cultures at day 60 of ATT showed a decreasing trend in the levels of ferritin and CRP (p<0.0001 for both). On the other hand, those that had positive cultures showed a slight decreasing trend in ferritin levels (p=0.0041) and no significant trend in CRP levels.

Finally, levels of CRP (p=0.0005) and ferritin (p=0.002) were significantly greater in patients with positive sputum cultures than those with negative sputum cultures at day 60.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Respirology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 08 Jun 2016
Middle East Respiratory Syndrome (MERS) patients have more severe illness and a higher mortality rate than non-MERS severe acute respiratory infection (SARI) patients, according to a study presented at the recent American Thoracic Society (ATS) International Conference 2016 held in San Francisco, California, US.
17 Jul 2017
There appears to be no evidence supporting associations between physical activity and asthma control level, spirometric measurements and quality of life in children and adolescents with asthma, according to a study from Brazil.
01 Feb 2016
Ampicillin/sulbactam is an effective first-line therapy among elderly patients with Nursing- and Healthcare- associated Pneumonia (NHCAP), as observed in a retrospective analysis.
Radha Chitale, 17 May 2016
Advanced non-small cell lung cancer (NSCLC) patients with uncommon mutations did not respond as well to first generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as those with more common mutations, according to a small, retrospective Japanese study presented at the IASLC Asia Pacific Lung Conference (APLCC) 2016, held recently in Chiang Mai, Thailand.