Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Corticosteroids with moxifloxacin effective against ACC with SLE

03 Aug 2017

Corticosteroids combined with the antibiotic moxifloxacin may be effective for the management of acute acalculous cholecystitis (AAC) with systemic lupus erythematosus (SLE), suggests a new observational study.

The investigators recruited 22 AAC patients with SLE who were receiving conservative management of either moxifloxacin alone (n=10; mean age 36.1±16.3 years) or in combination with corticosteroids (n=12; mean age 34.7±11.0 years). Study outcomes included improvement of symptoms and biochemical results, disease response and surgery.

The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI-2000) scores were significantly lower in the corticosteroid group than in the antibiotic alone group (7.3±1.4 vs 10.7±3.0; p=0.03). A similar trend was observed with the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SLICC/ACR) scores (0.1±0.3 vs 0.3±0.5; p=0.01).

The levels of antinuclear antibodies (1.3±0.4 vs 2.1±0.6 IU/mL; p=0.03), antidouble stranded DNA antibodies (40.0±8.3 vs 145.4±25.5 IU/mL; p=0.04) and anticardiolipin antibodies (17.9±4.5 vs 46.8±13.7 IU/mL; p=0.01) were significantly lower in the corticosteroid group than in the antibiotic group.

Significantly more patients in the corticosteroid group showed a positive response (p=0.01) and 11 of 12 patients were treated successfully. Only one patient in the corticosteroid group underwent cholecystectomy after treatment yielded no improvements.

By comparison, only four of 10 patients in the antibiotic alone group were successfully treated, and the remaining six had to undergo cholecystectomy because treatment conferred no improvements.

The rate of successful conservative treatment was thus significantly greater in the corticosteroid group than in the antibiotic group (p=0.02).

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.