Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Continuous-flow left ventricular assist devices linked to good long-term outcomes

30 Aug 2017

Continuous-flow left ventricular assist devices (CF-LVAD) confer excellent long-term survival, with prolonged LVAD support reducing the risk of major bleeds, a new study has shown.

The study included 103 adult patients (mean age 50±13 years; 71 percent male) undergoing CF-LVAD implantation. Patient demographic, preoperative comorbidity, laboratory, operative, medication and complication information were collected and included in the analysis.

Readmission information included interventional procedures required, length of stay and diagnosis. Elective transplant readmissions were excluded. Kaplan-Meier curves were used for survival analyses.

Over a mean follow-up of at least 2 years, overall mortality rate was only 29 percent (n=30), to which death during admission contributed the most (18 percent; n=19). The 30-day, 1-year and 2-year mortality rates were 14 (n=14), 23 (n=24) and 26 (n=27) percent, respectively.

Among the 37 patients who received prolonged LVAD support, there were 129 readmission events corresponding to 1,499 hospital days. Readmission at least once was reported in 29 patients, while nine were readmitted at least five times. There were four patients who were readmitted at least nine times.

The most common cause of readmission was major infections. All patients who were readmitted had at least one infection event. Seven patients had recurrent infections, while 15 had major infections during prolonged LVAD support.

Only postoperative infections were significantly associated with readmission (p=0.03). All-cause bleeding, ventricular arrhythmia and other complications after the operation were not significantly correlated with readmission. Mortality rates were also not significantly different between those who were readmitted and those who were not.

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Most Read Articles
Elvira Manzano, 6 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.