Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.

Continued statin therapy after adverse reaction reduces incidence of CV events, death

04 Aug 2017
Other experts stand firm that effectiveness of statins is well proven

Continuation of statin prescriptions even after having an adverse reaction is associated with a lower incidence of mortality and cardiovascular (CV) events, a recent study has found.

Researchers recruited patients (n=28,266) with a presumed adverse reaction to a statin between 2000 and 2011 in a retrospective cohort study to explore the relationship between continued statin therapy (any prescription within 12 months after an adverse reaction) and clinical outcomes.

Information on adverse reactions to statins was obtained from structured electronic medical record data or natural-language processing of narrative provider notes. Time to a CV event (myocardial infarction or stroke) or death was the primary composite outcome.

The text of electronic provider notes provided most of the adverse reactions to statins (81 percent). Of the patients, 19,989 (70.7 percent) continued receiving statin prescriptions after the adverse reaction.

The cumulative incidence of CV events or death was 12.2 percent for patients with continued statin prescriptions vs 13.9 percent for those who stopped receiving statins (difference, 1.7 percent; 95 percent CI, 0.8 to 2.7 percent; p<0.001) 4 years after the presumed adverse event.

Secondary analysis of 7,604 patients who received a different statin after the adverse reaction revealed that 2,014 (26.5 percent) had a documented adverse reaction to the second statin. However, 1,696 (84.2 percent) of these patients continued to receive statin prescriptions.

“The risk of recurrent adverse reactions to statins could not be established for the entire sample,” researchers said, adding that it was also not possible to determine whether patients actually took the statins.

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Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.