Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.

Concomitant use of TENS with oxybutynin effective in paediatric urge incontinence

14 days ago

Use of transcutaneous electrical nerve stimulation (TENS) in combination with oxybutynin in the treatment of urge incontinence in children is superior to both TENS and oxybutynin monotherapy in terms of efficacy, a study has shown. Treatment with TENS also helps reduce the risk of oxybutynin-induced elevated postvoid residual urine volume.

The study randomly assigned 66 children (mean age 7.3 years) with urge incontinence to one of the following treatment groups: active TENS plus active oxybutynin (group 1; n=22), active TENS plus placebo oxybutynin (group 2; n=21) and active oxybutynin plus placebo TENS (group 3; n=23).

Active or placebo TENS was administered over the sacral S2 to S3 outflow for 2 hours daily, whereas active or placebo oxybutynin was given at a dose of 5 mg dose twice daily. The intervention lasted for 10 weeks. Primary outcome was the number of wet days/week, while secondary outcomes included severity of incontinence, frequency, maximum voided volume (MVV)/expected bladder capacity (EBC), average voided volume (AVV)/EBC and visual analogue scale (VAS) score.

Combination therapy was superior to oxybutynin monotherapy (p=0.05), with the likelihood of response being 83-percent higher in children receiving combination therapy. Compared with active TENS monotherapy, active TENS/active oxybutynin was also significantly more effective in terms of improvement in number of wet days/week (mean difference [MD], -2.28; 95 percent CI, -4.06 to -0.49), severity of incontinence (MD, -3.11; -5.98 to -0.23) and voiding frequency per day (MD, -2.82; -4.48 to -1.17).

Urge incontinence is defined as an inability to suppress voiding with urgency, and overactive bladder is a common disorder of urge incontinence. Children with this disorder have small volume voids during the day, while those with infrequent voiding (<4 voids per day) may have voiding postponement. [Aust Prescr 2014;37:192-5]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Pearl Toh, 7 days ago
Mepolizumab added on to standard of care for patients with severe eosinophilic asthma better improves health-related quality of life (HRQOL), along with improved asthma symptoms and lung function compared with placebo, according to the MUSCA* study.
Pearl Toh, 6 days ago
Treatment with abiraterone acetate and prednisone for metastatic prostate cancer (mPC) in patients who responded poorly to initial androgen-deprivation therapy (ADT) showed encouraging results with favourable overall survival (OS) to historical controls, although the prespecified criteria for a positive result was not met , according to the S1014* trial.
5 days ago
Blood pressure (BP) ≥140/90 mm Hg appears to increase the risk of maternal complications and adverse foetal outcomes, irrespective of the number of medications used, a study suggests. However, the greatest risk is observed among pregnant women taking multiple agents and whose BP levels are within the aforementioned range.
7 days ago
Relapse after randomization is more likely to occur in patients with severe baseline hallucinations, reports a new study. In addition, the presence of baseline hallucinations is associated with a greater risk of relapse after discontinuation of risperidone vs continued risperidone treatment.