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Concomitant use of TENS with oxybutynin effective in paediatric urge incontinence

2 months ago

Use of transcutaneous electrical nerve stimulation (TENS) in combination with oxybutynin in the treatment of urge incontinence in children is superior to both TENS and oxybutynin monotherapy in terms of efficacy, a study has shown. Treatment with TENS also helps reduce the risk of oxybutynin-induced elevated postvoid residual urine volume.

The study randomly assigned 66 children (mean age 7.3 years) with urge incontinence to one of the following treatment groups: active TENS plus active oxybutynin (group 1; n=22), active TENS plus placebo oxybutynin (group 2; n=21) and active oxybutynin plus placebo TENS (group 3; n=23).

Active or placebo TENS was administered over the sacral S2 to S3 outflow for 2 hours daily, whereas active or placebo oxybutynin was given at a dose of 5 mg dose twice daily. The intervention lasted for 10 weeks. Primary outcome was the number of wet days/week, while secondary outcomes included severity of incontinence, frequency, maximum voided volume (MVV)/expected bladder capacity (EBC), average voided volume (AVV)/EBC and visual analogue scale (VAS) score.

Combination therapy was superior to oxybutynin monotherapy (p=0.05), with the likelihood of response being 83-percent higher in children receiving combination therapy. Compared with active TENS monotherapy, active TENS/active oxybutynin was also significantly more effective in terms of improvement in number of wet days/week (mean difference [MD], -2.28; 95 percent CI, -4.06 to -0.49), severity of incontinence (MD, -3.11; -5.98 to -0.23) and voiding frequency per day (MD, -2.82; -4.48 to -1.17).

Urge incontinence is defined as an inability to suppress voiding with urgency, and overactive bladder is a common disorder of urge incontinence. Children with this disorder have small volume voids during the day, while those with infrequent voiding (<4 voids per day) may have voiding postponement. [Aust Prescr 2014;37:192-5]

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Most Read Articles
Jairia Dela Cruz, 22 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 4 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
6 days ago
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