Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.

Cognitive restraint over eating may lower genetic susceptibility to obesity

12 Oct 2017

“Appetitive” eating behaviour traits, such as uncontrolled and emotional eating, tend to mediate genetic susceptibility to obesity, which is also modified by cognitive restraint, according to a recent study. In addition, elevated levels of cognitive control over eating tend to reduce genetic susceptibility to obesity.

Researchers calculated the genetic risk scores for body mass index (BMI-GRSs) for 3,515 and 2,154 in the Fenland and EDEN (Etude des déterminants pré et postnatals de la santé et du développement de l'enfant) population-based cohort studies, respectively.

A validated questionnaire was used to measure the following eating behaviours: emotional eating, uncontrolled eating and cognitive restraint. The Sobel test was utilized to evaluate the mediating effect of each eating behaviour on the association between the BMI-GRS and measured BMI. Researchers also tested for interactions between each eating behaviour and the BMI-GRS on BMI.

Both emotional (EDEN: p-Sobel=0.01; Fenland: p-Sobel=0.02) and uncontrolled eating (EDEN: p-Sobel=0.04; Fenland: p-Sobel=0.0006) mediated the association between BMI and BMI-GRS in both sexes combined. This association was not mediated by cognitive restraint (p-Sobel>0.10), except in EDEN women (p-Sobel=0.0009).

In addition, cognitive restraint modified the association between BMI and BMI-GRS among EDEN men (p=0.0001 for interaction; Fenland: p=0.04 for interaction) and Fenland women (p=0.0004 for interaction). The lowest tertile of cognitive restraint had the strongest association between BMI and BMI-GRS, while the highest tertile had the weakest.

“Future research into interventions designed to support restraint may help to protect genetically susceptible individuals from weight gain,” researchers said.

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Most Read Articles
01 Jun 2015
Long-term oral testosterone undecanoate significantly improved IPSS quality of life scores in a 1-year, randomised, multicentre, double-blind trial among aging hypogonadal men.
Rachel Soon, 01 Jun 2016

The inclusion of statins in managing chronic kidney disease (CKD) may help reduce patient mortality from stroke and possibly other cardiovascular events, according to an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Rachel Soon, 01 Jun 2016

Patients with hypercholesterolaemia with unchanging LDL-cholesterol levels after 6 weeks of statin treatment should be actively assessed for either statin intolerance or resistance, says an expert at the 7th Malaysian Endocrine and Metabolic Society (MEMS) Annual Congress.

Prof. Cyrus Rustam Kumana, 07 Jul 2016

This case scenario was presented at a grand round in the Department of Medicine, The University of Hong Kong. Unlike traditional grand rounds that directly or indirectly deal with clinical challenges posed by patients, this one was equally about doctors and how they care for their charges. All doctors who tend patients dread being implicated on the receiving end of medico-legal proceedings. This topic is therefore intimately linked to the professionalism of doctors, their standing in the community, and the ethical aspects of how they interact with patients and relatives.