Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Clomiphene citrate improves cycle characteristics, impairs IVF outcomes

06 Sep 2017
 Clomiphene citrate (CC) enhances cycle characteristics but may lead to poorer in vitro fertilization (IVF) outcomes in obese females with polycystic ovarian syndrome (PCOS) undergoing ovarian stimulation for IVF, a recent study has found.

Investigators divided 174 obese women with PCOS undergoing IVF into two groups according to treatments received: those who were given CC with human menopausal gonadotropin (HMG) and medroxyprogesterone acetate (MPA; n=90), and those who received HMG and MPA only (control; n=84).

HMG dose was significantly lower in the HMG+MPA+CC group (1,650 IU) compared with the control group (2,025 IU; p=0.0002038). In contrast, HMG stimulation duration between the two groups were comparable (11 vs 12 days; p=0.077).

The number of oocytes retrieved was significantly higher in the control group than in the study group (13 vs 5; p=0.0000016), while the time from trigger to retrieval of oocytes was comparable between groups.

The control group also had significantly higher numbers of mature oocytes (11 vs 4; p=0.00000386), fertilized oocytes (8 vs 4; p=0.000081) and cleaved embryos (8.5 vs 4 p=0.0000633) compared with the HMG+MPA+CC group.

The number of high quality embryos were also significantly greater in the control group than in the study group (3.5 vs 2; p=0.003).

Recruited participants underwent transvaginal ultrasound to measure antral follicle count and follicle size. Serum concentrations of relevant hormones were also recorded. The primary study outcome was the number of oocytes retrieved, while secondary outcomes included maturation rate, number of high quality embryos and fertilization rate.

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Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
22 Mar 2017
Patients often seek consultation at the pharmacy for superficial skin infection. The goal of this activity is to improve pharmacists' knowledge on strategies to manage bacterial skin infection.
 
Please click here to access this module
01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.