Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.

Changes in NT-proBNP tied to higher cardiovascular risk in NSTEACS

25 Jul 2017

Changes in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) are associated with cardiovascular risks in non-ST-segment elevation acute coronary syndrome (NSTEACS), a new study has shown.

In 1,665 NSTEACS patients (median age 65.0 years; 38.3 percent female), the change in NT-proBNP levels from baseline to six months was significantly associated with higher risks of CV death (hazard ratio [HR], 1.14; 95 percent CI, 1.03 to 1.27; p=0.01) and all-cause death (HR, 1.14; 1.04 to 1.26; p<0.01).

In comparison, only the risk of all-cause death was significantly associated with the change in NT-proBNP from baseline to 30 days (HR, 1.15; 1.03 to 1.28; p=0.01).

NT-proBNP levels at baseline and at 30 days were associated significantly with cardiovascular (CV) death (HR, 1.17; 1.07 to 1.28; p<0.01 and HR, 1.24; 1.09 to 1.41; p<0.01, respectively), all-cause death (HR, 1.15; 1.06 to 1.25; p<0.01 and HR, 1.23; 1.09 to 1.38; p<0.01, respectively) and CV events (HR, 1.07; 1.01 to 1.14; p=0.02 and HR, 1.11; 1.02 to 1.22; p=0.02, respectively).

Additionally, NT-proBNP levels at 6 months were also significantly associated with CV events (HR, 1.13; 1.04 to 1.24; p<0.01), CV death (HR, 1.20; 1.08 to 1.33; p<0.01), myocardial infarction (MI; HR, 1.15; 1.02 to 1.30; p=0.02) and all-cause death (HR, 1.18; 1.07 to 1.29; p<0.01).

On the other hand, only the change in hs-CRP from baseline to 6 months was associated with higher risks of CV events (HR, 1.09; 1.02 to 1.17; p=0.02) and myocardial infarction (HR, 1.10; 1.00 to 1.20; p=0.04).

NT-proBNP and hs-CRP levels were measured at three timepoints: at baseline, at 30 days and at 6 months. The primary endpoint was the composite outcome of CV death, nonfatal stroke and nonfatal MI. Cox proportional hazards was used to determine the correlation of biomarker levels with cardiovascular outcomes.

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Most Read Articles
Roshini Claire Anthony, 11 Oct 2017

The prevalence of resistant hypertension may be lower than expected, particularly once pseudo-resistant hypertension due to treatment nonadherence is taken into account, according to a presentation at the recent APCH 2017.

Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Tristan Manalac, 12 Oct 2017
Administration of a long-acting medication at the time that is most suitable for maximum patient compliance is the best approach in controlling blood pressure, said Dr. Trefor Morgan at the recently concluded 13th Asian-Pacific Congress of Hypertension (APCH 2017), held at the Suntec Singapore Convention and Exhibition Centre.
Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.