Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Cerebrospinal fluid B cells do not predict multiple sclerosis progression

10 Aug 2017

B cell subtypes in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients are not predictors of disease progression, expanded disability status scale (EDSS) progression or conversion to clinical definite MS (CDMS), a recent longitudinal prospective study has shown.

Over a median follow-up period of 7.9 years, CSF samples were extracted from 40 clinically isolated syndrome (CIS), 27 relapsing remitting MS (RRMS), two secondary progressive MS (SPMS) and nine primary progressive MS (PPMS) patients. A control group of 40 patients with other neurological diseases (OND) was included.

Older age at baseline (odds ratio [OR], 1.7; 95 percent CI, 1.0 to 3.0; p=0.041) was the only significant prognostic factor for MS progression after comparing the SPMS and PPMS with the CIS and RRMS patients.

There were no significant associations found for sex (OR, 0.3; 0.0 to 3.8; p=0.380), duration of disease (OR, 1.3; 0.9 to 1.9; p=0.097), CD19+CD138- cells (OR, 0.0; 0.0 to 7.8; p=0.166) or CD19+CD138+ cells (OR, 0.5; 0.0 to 26.3; p=0.736).

Similarly, age at baseline (OR, 1.1; 1.0 to 1.1; p=0.012) was the only significant prognostic factor for EDSS progression. CD19+CD138- (OR, 0.1; 0.0 to 1.2; p=0.077) and CD19+CD138+ (OR, 1.6; 0.4 to 6.7; p=0.531) cells were not significantly correlated.

On the other hand, flow cytometry analysis showed that the majority of B cells in the CSF of MS patients were either CD19+CD138- mature B cells or CD19+CD138+ plasmablasts. At follow-up, the CSF composition of CIS, RRMS and SPMS patients were significantly different from the OND controls (p<0.001). PPMS CSF composition did not significantly differ from OND CSF composition.

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Most Read Articles
Elvira Manzano, 17 Oct 2017
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Drinking coffee, whether caffeinated or decaffeinated, is associated with a reduced risk of cardiovascular disease (CVD) and ischaemic heart disease (IHD) mortality in patients with a prior myocardial infarction (MI), according to a recent study.
3 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 3 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.