Most Read Articles
11 Aug 2017
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
2 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 4 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.

Cerebrospinal fluid B cells do not predict multiple sclerosis progression

10 Aug 2017

B cell subtypes in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients are not predictors of disease progression, expanded disability status scale (EDSS) progression or conversion to clinical definite MS (CDMS), a recent longitudinal prospective study has shown.

Over a median follow-up period of 7.9 years, CSF samples were extracted from 40 clinically isolated syndrome (CIS), 27 relapsing remitting MS (RRMS), two secondary progressive MS (SPMS) and nine primary progressive MS (PPMS) patients. A control group of 40 patients with other neurological diseases (OND) was included.

Older age at baseline (odds ratio [OR], 1.7; 95 percent CI, 1.0 to 3.0; p=0.041) was the only significant prognostic factor for MS progression after comparing the SPMS and PPMS with the CIS and RRMS patients.

There were no significant associations found for sex (OR, 0.3; 0.0 to 3.8; p=0.380), duration of disease (OR, 1.3; 0.9 to 1.9; p=0.097), CD19+CD138- cells (OR, 0.0; 0.0 to 7.8; p=0.166) or CD19+CD138+ cells (OR, 0.5; 0.0 to 26.3; p=0.736).

Similarly, age at baseline (OR, 1.1; 1.0 to 1.1; p=0.012) was the only significant prognostic factor for EDSS progression. CD19+CD138- (OR, 0.1; 0.0 to 1.2; p=0.077) and CD19+CD138+ (OR, 1.6; 0.4 to 6.7; p=0.531) cells were not significantly correlated.

On the other hand, flow cytometry analysis showed that the majority of B cells in the CSF of MS patients were either CD19+CD138- mature B cells or CD19+CD138+ plasmablasts. At follow-up, the CSF composition of CIS, RRMS and SPMS patients were significantly different from the OND controls (p<0.001). PPMS CSF composition did not significantly differ from OND CSF composition.

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Most Read Articles
11 Aug 2017
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
2 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 4 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.