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Roshini Claire Anthony, 6 days ago

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CBT-fluoxetine combo therapy outperforms single treatment for hypochondriasis

06 Aug 2017

A recent study has shown the safety, efficacy and tolerance of fluoxetine for hypochondriasis. Moreover, joint treatment with both fluoxetine and cognitive behavioural therapy (CBT) confers a small incremental benefit over a single active treatment.

To determine whether joint treatment provides additional benefit, researchers randomized 195 patients with DSM-IV hypochondriasis to one of four treatments: placebo, CBT, fluoxetine, or joint treatment with fluoxetine and CBT. Analyses focused on hypochondriasis, adverse events, quality of life, functional status and other psychopathology.

At week 24, outcome was assessed among the intent-to-treat patients, with responders defined as having a ≥25-percent improvement over baseline on both the Whiteley Index and a modified version of the Yale-Brown Obsessive Compulsive Scale for hypochondriasis (H-YBOCS-M).

The Cochran-Armitage trend test assessed the hypothesized pattern of response: joint treatment > CBT or fluoxetine treatment > placebo treatment.

There was a statistically significant predicted pattern of response as shown by the following responder rates: joint treatment group, 47.2 percent; single active treatment group, 41.8 percent; and placebo group, 29.6 percent. There was no significant difference between responder rates for each active treatment and the rate for placebo.

Based on secondary analyses of the Whiteley Index as a continuous measure, fluoxetine was more effective at week 24 in reducing hypochondriasis and had a significantly faster rate of improvement over 24 weeks than placebo. Fluoxetine also led to significantly less anxiety and better quality of life compared with placebo.

Dropout rates were not different between groups. In addition, there was an even distribution of treatment-emergent adverse events.

According to researchers, “[b]ecause approximately 50 percent of patients did not respond to the study treatments, new or more intensive approaches are needed.”

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.