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Carotid artery reactivity may help assess cardiovascular risk

21 Apr 2017

Lower carotid artery reactivity (CAR%) correlates with older age and cardiovascular risk factors, whereas CAR% demonstrates positive association with coronary artery responses to the cold pressor test (CPT), a recent study has found.

Researchers used ultrasound to measure both resting and peak carotid artery diameters during the CPT, with CAR% being calculated as the relative change from baseline (%). CAR% was compared between young (n=50; 24 ±3 years) and older participants (n=44; 61 ±8 years); the relationships between CAR% and traditional cardiovascular risk factors in 50 participants (44 ±21 years) were also evaluated.

Using transthoracic Doppler echocardiography, a fundamental instrument to understand heart damage during essential arterial hypertension, researchers then compared the left anterior descending (LAD) artery velocity with carotid artery diameter (ie, CAR%) during the CPT (n=33; 37 ±17 years). [J Cardiovasc Med (Hagerstown) 2007;8:997-1006]

CAR% was significantly larger in young compared with older healthy participants (4.1 vs 1.8; p<0.001). Participants with no cardiovascular risk factors showed greater CAR% than those with at least two risk factors (2.9 vs 0.5; p=0.019).

During CPT, both the carotid artery diameter and LAD velocity increased (p<0.001). Carotid diameter (r=0.486; p<0.004) and change in velocity (r=0.402; p<0.02) were both associated with LAD velocity.

“Therefore, CAR% may represent a valuable technique to assess cardiovascular risk, while CAR% seems to reflect coronary artery vasodilator function,” according to researchers.

CAR%, which involves carotid artery diameter responses to a CPT, is a noninvasive measure of conduit artery function in humans, they added.

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Most Read Articles
Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Tristan Manalac, 2 days ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.
15 Oct 2017
Second eye cataract surgery provides greater improvement in visual function and quality of life compared with first eye cataract surgery alone, a recent study claims.