Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
02 Aug 2017
Inappropriate prescription of anaerobic antibiotics to intensive care unit (ICU) patients admitted with pneumonia frequently occurs, with the prescription associated with prolonged length of stay (LOS) in the ICU, a study has found.
Pearl Toh, 01 Aug 2017
Daily intake of B vitamins did not improve cognitive function in patients with small vessel disease, in addition to previous findings that it was not protective against major vascular events in patients who had a recent stroke or transient ischaemic attack, according to a substudy of the VITATOPS* trial.

Canagliflozin decreases serum uric acid level in diabetic patients with or without baseline hyperuricaemia

Fiel Soliven
01 Apr 2015
Hyperuricaemia is associated with numerous diseases; thus, decreasing serum uric acid may be beneficial for type 2 diabetes mellitus (T2DM) patients. The effects canagliflozin on serum acid levels of T2DM patients and a subset who have hyperuricaemia were assessed in this review article.

The present post hoc analysis of four placebo-controlled phase III trials revealed that canagliflozin is connected to an approximately 13 percent decrease in serum acid compared to placebo. Also, 23.5 and 32.4 percent of hyperuricaemic patients who received canagliflozin 100 and 300 mg, respectively, attained serum uric acid level of < 360 µmol/L (~ 6 mg/dL) compared to the 3.1 percent with placebo. The occurrence of kidney stones and gout were also low and similar throughout the groups.

Canagliflozin was concluded to lower serum uric acid in T2DM patients, including those who have hyperuricaemia initially.
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Most Read Articles
01 Sep 2016
Digoxin, as a new or preexisting therapy, does not increase mortality following acute phase of ST-elevation myocardial infarction (STEMI), as shown in the MAGIC study.
15 Apr 2016
Addition of digoxin to an ACE inhibitor lessens heart failure (HF) hospitalisation in HF patients with reduced ejection fraction, regardless of diabetes status, as presented in an analysis of the Digitalis Investigation Group trial.
02 Aug 2017
Inappropriate prescription of anaerobic antibiotics to intensive care unit (ICU) patients admitted with pneumonia frequently occurs, with the prescription associated with prolonged length of stay (LOS) in the ICU, a study has found.
Pearl Toh, 01 Aug 2017
Daily intake of B vitamins did not improve cognitive function in patients with small vessel disease, in addition to previous findings that it was not protective against major vascular events in patients who had a recent stroke or transient ischaemic attack, according to a substudy of the VITATOPS* trial.