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Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
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Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Bmi-1 overexpression tied to distant metastasis, poor survival in NSCLC

22 Jul 2017

Overexpression of B-cell-specific Moloney leukaemia virus insertion site 1 (Bmi-1) is associated with poor overall survival (OS), distant metastasis and tumour size in nonsmall cell lung cancer (NSCLC), according to a new meta-analysis.

Pooled data from 14 studies (n=1,323) showed that Bmi-1 overexpression was significantly associated with tumour size (n=7; odds ratio [OR], 1.79; 95 percent CI, 1.19 to 2.71; p=0.005), poor differentiation (n=7; OR, 1.61; 1.11 to 2.33; p=0.011) and distant metastasis (n=4; OR, 4.69; 1.52 to 14.41; p=0.007).

Similarly, pooled data from eight studies (n=913) showed that Bmi-1 overexpression was significantly associated with poor survival in NSCLC patients (hazard ratio [HR], 1.62; 1.14 to 2.3; p<0.001).

In contrast, Bmi-1 expression showed no significant associations with age (OR, 1.13; 0.86 to 1.49; p=0.372), tumour/node/metastasis staging (OR, 0.91; 0.68 to 1.22; p=0.513), lymph node metastasis (OR, 1.25; 0.71 to 2.22; p=0.434), histology (OR, 1.07; 0.73 to 1.57; p=0.722) and smoking (OR, 1.2; 0.78 to 1.86; p=0.402).

The meta-analysis involved studies that investigated the relationship of Bmi-1 expression and clinical factors and overall survival in histologically confirmed NSCLC patients. Studies that reported HRs and ORs were included, while those that were case studies or animal studies were excluded. The databases of PubMed, Web of Science and Embase were accessed.

Begg test and Egger test were both employed to evaluate the risk of bias of the selected studies. None of the studies showed publication bias.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.