Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

BMI, fat free mass, irisin levels drop after high altitude climbing

04 Aug 2017
Viagra may be useful in HAPE prevention and treatment, but not for AMS or HACE.

Body mass, body mass index (BMI), irisin, 25-hydroxyvitamin D (25(OH)D) levels and fat free mass decrease significantly after hypobaric hypoxia from high-altitude climbing, a new study shows.

On the other hand, hypobaric hypoxia increases myoglobin, interleukin (IL)-6, osteoprotegerin (OPG) and high-sensitivity C-reactive protein (hsCRP) levels.

A total of eight males (mean age 27±2.8 years) who underwent a 2-week climbing expedition in the Alps were subjected to body composition measurements. Concentrations of hsCRP, myoglobin, irisin, 25(OH)D, OPG and other biomarkers were measured from collected blood samples.

Body mass (72.3±6.05 vs 70.7±5.18 kg), BMI (22.7±1.27 vs 22.2±0.83 kg/m2) and fat-free mass (84.2±2.36 vs 84.1±2.78 percent) decreased significantly from baseline following 2 weeks of hypobaric hypoxia (p<0.05 for all). Similarly, levels of 25(OH)D and irisin decreased significantly from baseline (p<0.05 for both).

On the other hand, concentrations of OPG, IL-6, hsCRP and myoglobin significantly increased compared with baseline values (p<0.05 for all).

Lean body mass was significantly positively associated with irisin levels at baseline (p=0.0009) and after the expedition (p=0.0366). Similarly, hsCRP was positively associated with OPG (p=0.0465) and with the ratio between OPG and high sensitivity soluble receptor activator of NF-κB ligand (sRANKL; p=0.0102) after the expedition.

Significant positive correlations were also found between IL-6 and myostatin (p=0.028), irisin and 25(OH)D (p=0.0366), hsCRP concentrations and OPG/sRANKL ratio (p=0.0009), and myostatin levels and OPG/sRANKL ratio (p=0.0065).

According to the investigators, these results suggest that certain myokines may play a role in skeletal muscle regeneration and energy processes following hypobaric hypoxia exposure.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.