Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Bioresorbable scaffolds deliver more intense expansive remodeling than metallic stents

06 Jul 2017

Implantation of a bioresorbable vascular scaffold (BVS), compared with metallic drug-eluting stent (DES), leads to more frequent and intense expansive vessel wall remodeling, which can be determined by patient baseline characteristics and periprocedural factors, a recent study has found.

Researchers compared vessel remodeling pattern following either Absorb BVS or Xience metallic DES implantation and determined the independent predictors or remodeling. They investigated 383 lesions (n=359) by ultrasound in the ABSORB II randomized trial, both postprocedure and at 3-year follow-up.

The authors categorized nine patterns of vessel remodeling that were beyond the reproducibility of lumen and vessel area measurements based on changes in vessel and lumen area over 3 years.

BVS had significantly greater relative change in mean vessel area vs DES (6.7±12.6 vs 2.9±11.5 percent; p=0.003); the two arms had significantly different relative change in mean lumen area (1.4±19.1 vs ‒1.9±10.5 percent, respectively; p=0.031).

In multivariate analysis, the independent predictors of expansive remodeling were BVS use, female sex, balloon-artery ratio >1.25, expansion index ≥0.8, previous percutaneous coronary intervention and higher level of low-density lipoprotein cholesterol. In addition, necrotic core preprocedure was an independent determinant of expansive remodeling in the BVS group.

“The clinical effect of the observed lumen and vessel remodeling must be investigated in further large clinical studies to optimize the clinical outcome of patients and lesions treated by bioresorbable scaffolds,” researchers said.

Previous observational studies have documented late luminal enlargement and expansive remodeling after BVS implantation, but no comparison with metallic stents has been performed in a randomized fashion, they added.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.