Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.

Biological outdoes conventional synthetic DMARD for psoriatic arthritis

12 Aug 2017
A new therapy is now available to patients who cannot tolerate DMARDs.

The use of biological disease-modifying antirheumatic drugs (bDMARD) is associated with a minimal disease activity (MDA) status and remission in patients with psoriatic arthritis (PsA) as compared to conventional synthetic (cs)DMARD, according to a recent study.

Additionally, it appears that Psoriatic Arthritis Disease Activity Score (PASDAS) ≤1.9 and MDA 7/7 are stringent remission criteria.

Researchers enrolled patients with PsA (n=109) categorized using the CASPAR criteria and with >6 months follow-up treated with first csDMARD and bDMARD. They assessed disease activity using composite indices tailored for PsA, such as the Disease Activity Index for Psoriatic Arthritis (DAPSA), clinical (c)DAPSA, PASDAS, MDA 5/7 and MDA 7/7.

Remission was identified by DAPSA and cDAPSA score ≤4, MDA 7/7, and PASDAS ≤1.9. MDA and low disease activity (LDA) criteria were identified by MDA 5/7, DAPSA score ≤14, cDAPSA score ≤13 and PASDAS <3.2.

Of the patients enrolled, 79 were receiving stable treatment with bDMARD and 30 with csDMARD.

In general, there were 28 patients (25.6 percent) in cDAPSA remission, 23 (21.1 percent) in DAPSA remission, 19 (17.4 percent) in MDA 7/7 and 13 (11.9 percent) in PASDAS ≤1.9. In addition, 54 patients (49.5 percent) were in MDA 5/7, 80 (73.3 percent) in DAPSA LDA, 79 (72.3 percent) in cDAPSA LDA and 38 (34.8 percent) in PASDAS LDA.

Compared with patients treated with csDMARD, those treated with bDMARD had significantly lower median DAPSA, cDAPSA and PASDAS score.

According to researchers, there are several methods available to define remission or LDA in a complex disease such as PsA.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

Treatment failure in osteoporosis remains a problem, even among patients who are treatment-adherent, according to a presentation at the recent meeting of the Asian Federation of Osteoporosis Societies (AFOS 2017), held in Kuala Lumpur, Malaysia. 

Elvira Manzano, 5 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
2 days ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.