Most Read Articles
11 Aug 2017
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
2 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 4 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.

Biologic potential of rare pigmented epithelioid melanocytome remains unclear

31 Jul 2017

A recent study shows that pigmented epithelioid melanocytome (PEM) tends to exhibit an indolent behaviour, but current evidence is too limited to provide insight into its true biologic potential.

Researchers probed the pathology database for cases of PEM diagnosed at the University of Rochester and reviewed charts for follow-up information. In two cases, multinational analysis of melanoma-associated genes was conducted.

A 10-year retrospective review yielded nine cases of PEM. There were five patients who underwent sentinel lymph node biopsy, of whom three had a positive sentinel lymph node. All nine patients are alive and disease-free, with average 38.75 months of follow-up.

Two tumours were examined for common melanoma-related mutations. The samples tested negative, except for a telomerase reverse transcriptase promoter deletion detected in one tumour. Such deletion did not correlate with melanoma; thus, its biologic significance remains unclear.

The findings of this study should be interpreted in light of its limitations, which included a small sample size, a retrospective design and a single institution experience, according to researchers.

A recently described entity with unknown biologic behaviour, PEM is a rare, heavily pigmented, borderline, melanocytic tumour with infiltrative borders, which has potential for frequent metastases but shows an indolent clinical course. Epithelioid and spindled melanocytes with heavy pigmentation comprise these tumours.  [Eplasty 2016;16;16:e33]

A Japan study presented in 2009 reported PEM cases that might have been previously diagnosed as cellular blue nevus. Researchers suggested that Japanese pathologists must recognize a new concept of PEM, which should be recommended sentinel lymph node sampling when they make such a diagnosis. [J Cutan Pathol 2009;36:439-43]

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
11 Aug 2017
Magnetoencephalography (MEG) can detect functional network alterations accompanied by amyloid-β (Aβ) deposition in cognitively normal (CN) elderly adults before anatomical changes can be observed, a new study shows.
2 days ago
At least one dose of the 13-valent pneumococcal conjugate vaccine (PCV13) has high individual vaccine effectiveness (VE) in preventing invasive pneumococcal disease (IPD) in a paediatric population with suboptimal vaccination coverage, a new study has shown.
09 Aug 2017
Longer sleep duration is positively associated with better metabolic profiles, a new study has shown. On the other hand, there is no direct correlation between sleep duration and dietary intake.
Jairia Dela Cruz, 4 days ago
Capecitabine appears to provide additional survival benefit in triple-negative breast cancer patients treated with standard chemotherapy, significantly improving disease-free survival and overall survival but potentially increasing adverse events consistent with the drug’s known toxicity profile, according to a meta-analysis.