Most Read Articles
Pearl Toh, one year ago
Middle East Respiratory Syndrome (MERS) patients have more severe illness and a higher mortality rate than non-MERS severe acute respiratory infection (SARI) patients, according to a study presented at the recent American Thoracic Society (ATS) International Conference 2016 held in San Francisco, California, US.
one year ago
Beclomethasone and formoterol combination pressurised metered-dose inhaler is effective for long-term asthma management, as revealed in the CASPER noninterventional, observational trial in Poland.
one year ago
Peak nasal inspiratory flow is as favourable as formal rhinomanometry as a marker of objective nasal patency but is cheaper, simpler, and more appropriate for serial measurements and home use according to a review.
Jairia Dela Cruz, one year ago
A group of allergens uniquely expressed in paediatric patients with persistent troublesome (PT) wheeze holds potential value as biomarkers in differentiating between troublesome and controlled wheezing, according to a study presented at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2016 held in Vienna, Austria.

Asthma a risk factor for myelodysplastic syndrome

5 months ago

Asthma may contribute to an added risk of developing myelodysplastic syndrome or chronic myelomonocytic leukaemia (CMML), a recent study suggests.

Researchers looked at a cohort of patients with a first-time hospital-based asthma diagnosis to examine whether asthma was directly related to the development of myelodysplastic syndrome. The total study population comprised 75,995 patients with incident asthma and no history of myelodysplastic syndrome or CMML.

Of the patients, 78 and 9 developed myelodysplastic syndrome and CMML, respectively, during 402,892 person-years.

The cumulative risks of developing myelodysplastic syndrome and CMML were 0.02 percent (95 percent CI, 0.01 to 0.04) and 0.07 percent (0.05 to 0.09) during the first year and the first five years of follow-up, respectively.

Myelodysplastic syndrome and CMML had a standardized incidence ratio of 1.6 (1.3 to 2.0) among asthma patients overall, with little difference across subgroups.

The role of allergies in the development of hematopoietic malignancies is unclear. One potential explanation for this association is the antigen stimulation theory, which suggests that the immune system of allergic individuals is perpetually stimulated by allergens, inducing chronic inflammation, stimulation of cell proliferation and, ultimately, increased risk of malignancy. [Cancer Epidemiol Biomarkers Prev 2014;23:1903–1912]

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Most Read Articles
Pearl Toh, one year ago
Middle East Respiratory Syndrome (MERS) patients have more severe illness and a higher mortality rate than non-MERS severe acute respiratory infection (SARI) patients, according to a study presented at the recent American Thoracic Society (ATS) International Conference 2016 held in San Francisco, California, US.
one year ago
Beclomethasone and formoterol combination pressurised metered-dose inhaler is effective for long-term asthma management, as revealed in the CASPER noninterventional, observational trial in Poland.
one year ago
Peak nasal inspiratory flow is as favourable as formal rhinomanometry as a marker of objective nasal patency but is cheaper, simpler, and more appropriate for serial measurements and home use according to a review.
Jairia Dela Cruz, one year ago
A group of allergens uniquely expressed in paediatric patients with persistent troublesome (PT) wheeze holds potential value as biomarkers in differentiating between troublesome and controlled wheezing, according to a study presented at the European Academy of Allergy and Clinical Immunology (EAACI) Congress 2016 held in Vienna, Austria.