Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

Fiel Soliven, 2 years ago
The connection between prediabetes, diabetes, and risk of hepatocellular carcinoma (HCC) in HBsAg and anti-HCV seronegative patients, as well as the association between fasting glucose and HCC were examined in this study.
10 months ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Aseptic technique did not reduce LOS in infants

Elaine Soliven
15 days ago

Strict aseptic technique for parenteral nutrition (PN) line management did not significantly reduce the incidence of late-onset sepsis (LOS) in very low birth weight (VLBW) infants compared with standard technique, according to a recent study.

“The bundle of PN line management employing a two-nurse sterile technique and measures to reduce breaches of lines used to infuse the PN did not reduce the incidence of LOS in infants of <1500 g birth weight,” according to the researchers.

In this prospective randomized controlled trial, 249 infants (birth weight, <1500 g) were randomized to aseptic technique group (n=126) or standard technique group (n=123). [BMC Pediatrics 2017;doi:10.1186/s12887-017-0855-3]

There was no significant difference in sepsis outcomes in the aseptic technique group compared with the standard technique group (31.8 percent vs 29.3 percent; p=0.77). Majority of the sepsis episodes occurred during the first 28 days of life.

In a subgroup analysis for infants with birth weight of <1000 g, 45.9 percent (n=28) of participants in the aseptic technique group and 38.3 percent (n=23) in the standard technique group reported an episode of LOS.

 “After adjustment for birth weight, receiving PN was the factor associated with the greatest risk,” said the researchers, which was consistent with previous studies that have implicated PN as an important risk factor for LOS. [Pediatr Infect Dis J 1998;17:10-17; Am J Perinatol 2015;32:675-682; Am J Infect Control 2001;29:109-114]

 “The results of our study were unexpected and the reasons for the lack of effectiveness of the study intervention remain unclear. It is possible that awareness among staff in the NICU that management of PN lines may affect risk for LOS might have improved diligence with respect to management of all PN lines, affecting LOS incidence in the control group,” said the researchers.

Given the lack of evidence to recommend aseptic technique as a routine practice, further research is recommended to evaluate other potentially effective methods in reducing LOS.
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Most Read Articles
3 years ago

WHO (2012) estimates that around 450 million people suffer from mental illness, with one–in–four families having at least one member with a mental illness at any point in time. According to the Malaysian Mental Health Association, mental illness is often misunderstood. For centuries, it has been seen as either possession by evil spirits, a moral weakness or punishment from a higher being. Those suffering from mental illness are commonly perceived to be restless, violent and unpredictable.

Fiel Soliven, 2 years ago
The connection between prediabetes, diabetes, and risk of hepatocellular carcinoma (HCC) in HBsAg and anti-HCV seronegative patients, as well as the association between fasting glucose and HCC were examined in this study.
10 months ago
Orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were effective in achieving weight loss among overweight and obese adults at 52 weeks, a recent study found. Phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss.
one year ago
New drug applications approved by US FDA as of 16 - 31 Dec 2015 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.