Most Read Articles
Jairia Dela Cruz, 22 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 4 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
6 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.

Antithymocyte globulin following non-MSDT improves survival in MDS patients

3 months ago

Antithymocyte globulin (ATG) is associated with improved survival and a lower rate of nonrelapse morbidity (NRM) in patients with myelodysplastic syndromes (MDS) receiving non-matched sibling donor transplant (MSDT), a new study reveals.

The study retrospectively investigated the data of 85 patients with MDS who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). Endpoints of the study were overall survival (OS), overall survival post-transplant (OSPT), NRM and relapse.

A hundred days after transplantation, 28 patients (35.9 percent) developed grades I-II of acute graft-versus-host disease (GVHD), while 15 patients (19.2 percent) developed grades III-IV. Moreover, 69.4 percent of patients with evaluable infections had bacterial or fungal infections. The most common infection was pneumonia.

Of the 85 patients, 16 (18.8 percent) had relapses. The cumulative incidence of relapses was 14, 23 and 27 percent during the first, second and third years, respectively. There was no significant difference in relapse incidence between MSDT and non-MSDT patients (p=0.932).

Furthermore, ATG involvement in the regimen did not affect the risk of relapse after transplant. Intensive chemotherapy or decitabine therapy also did not influence the risk of relapse compared to supportive pre-HSCT care (p=0.107).

A total of 38 patients died; 30 deaths were caused by NRM. The cumulative incidences of NRM was 13, 23 and 28 percent during the first, second and third years. Compared to non-MSDT patients, NRM was higher in MSDT patients. The ATG cohort also showed significantly fewer NRM cases (p=0.03).

OS during the first, second and fifth years was 63, 57 and 48 percent, respectively. OSPT probabilities were 58, 55 and 48 percent for the first, second and fifth years, respectively.

Finally, the median OSPT in non-MSDT patients was significantly better than in MSDT patients (p=0.042), while using ATG improved OS (p=0.016) and OSPT (p=0.025) after non-MSDT.

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Most Read Articles
Jairia Dela Cruz, 22 days ago
Statins appear to have a dose-dependent association with the risk of tuberculosis (TB), with a nationwide population-based study showing that statin users have 47 percent lower incidence of TB compared with nonusers.
one month ago
At a recent lunch symposium during the 14th Annual Scientific Meeting of the Malaysian Society of Hypertension, Dr Chow Yok Wai spoke on the importance of patient adherence in the management of hypertension, highlighting the role of combination therapy in improving treatment outcomes.
Pearl Toh, 4 days ago
Individuals with high fasting plasma glucose (FPG) lost more weight than those who had low FPG in response to a high-fibre, low glycaemic load diet, suggesting that FPG could be used as a biomarker to predict dietary weight loss success and to guide selection of the most effective diet, in particular for those with prediabetes and diabetes, according to studies presented at ADA 2017.
6 days ago
Mesalazine is not superior to placebo in terms of preventing recurrence in patients with diverticulitis, according to data from two phase III trials.