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2 years ago
The treatment armamentarium of atopic dermatitis (AD) includes pharmaceuticals like emollients, topical corticosteroids, and topical calcineurin inhibitors. Recently available, medical devices are a newer class of topical, non-steroidal, semi-solid formulation for the treatment of AD and touted to possess emollient, anti-inflammatory, and anti-pruritic properties. To determine the role of medical devices in flare and remission management in AD, a panel of local experts from the field of dermatology, paediatric dermatology, and allergy convened to review the available evidence and highlights of the meeting are reported here.
2 years ago
Hair loss is a common problem for both men and women. Despite the various treatments available, hair loss remains a difficult condition to treat in most people. To gain better insights into the science behind hair loss, an interview was conducted recently with Dr Jia-Wei Liu, member of the European Hair Research Society and Vice President of Research and Development at Legacy Healthcare, Switzerland. The interview focused on hair loss and its management with CG 210TM, a novel botanical hair and scalp essence. 
5 days ago
There is a marked difference in the thickness of the granular layer between palmar psoriasis and hand eczema, and this may be helpful in differentiating between the two skin conditions, according to a recent study.
Jan Welch, 6 years ago

Sexually transmitted infections (STIs) are common, with rates of many infections increas­ing over the last two decades.1 Community screening studies in the UK have shown a prevalence of about 10% for chlamydial infection2 and (among women screened in an urban setting) 3% for gonorrhoea.3 In women (Figure 1), these potentially serious infections are often asymptomatic, whereas the presence of symptoms such as vaginal discharge generally indicates a less pathogenic (but still potentially debilitating) infection, with an organism such as Candida. STIs are often multiple, and the finding of one infection should prompt consider­ation of testing for others. Many sexual health services now initially provide screening tests for asymptomatic women, but a more comprehensive assessment—comprising detailed history4 and genital examination5—is usually necessary when symptoms are present.

Antimuscarinic acetylcholine receptor antibody strongly related to pemphigus

2 months ago
A woman who developed severe allergic reactions to anti-depressants nearly died from Steven Johnson Syndrome

A strong association exists between antimuscarinic (anti-M3) acetylcholine receptor (AchR) antibodies and pemphigus, according to a study. In addition, anti-M3 AchR antibodies significantly correlate with disease activity, and their titers decline with therapy along with antidesmoglein (anti-Dsg) antibodies.

Researchers performed a hospital-based cohort study involving 45 patients with active pemphigus to evaluate the changes in anti-M3 AchR and anti-Dsg antibody titers with therapy. The Pemphigus Disease Area Index was used to clinically grade the disease. Antibody titers were estimated using enzyme-linked immunosorbent assay at baseline, 3 and 15 months.

Compared with a control group, all patients with pemphigus had significantly greater anti-M3 AchR titers. Only 95.5 and 84.4 percent of patients had anti-Dsg1 and anti-Dsg3 antibodies, respectively.

The findings showed a statistically significant decrease in all three antibody titers from baseline to follow-up with treatment. All three antibody titers had a good association with Pemphigus Disease Area Index score at baseline and after therapy. Also, there was a good correlation between anti-M3 AchR and anti-Dsg1 antibody titers.

The small sample size and short follow-up period were the limitations of the study, according to researchers.

A group of bullous diseases that affect the oral mucosa and the skin, pemphigus is caused by antibody-mediated autoimmune reaction to Dsg, desmosomal transmembrane glycoproteins, leading to acantholysis. It is categorized into pemphigus vulgaris (PV), with suprabasal acantholysis, and pemphigus foliaceus (PF), with acantholysis in the more superficial epidermis. [Minerva Stomatol 2007;56:215-23]

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Most Read Articles
2 years ago
The treatment armamentarium of atopic dermatitis (AD) includes pharmaceuticals like emollients, topical corticosteroids, and topical calcineurin inhibitors. Recently available, medical devices are a newer class of topical, non-steroidal, semi-solid formulation for the treatment of AD and touted to possess emollient, anti-inflammatory, and anti-pruritic properties. To determine the role of medical devices in flare and remission management in AD, a panel of local experts from the field of dermatology, paediatric dermatology, and allergy convened to review the available evidence and highlights of the meeting are reported here.
2 years ago
Hair loss is a common problem for both men and women. Despite the various treatments available, hair loss remains a difficult condition to treat in most people. To gain better insights into the science behind hair loss, an interview was conducted recently with Dr Jia-Wei Liu, member of the European Hair Research Society and Vice President of Research and Development at Legacy Healthcare, Switzerland. The interview focused on hair loss and its management with CG 210TM, a novel botanical hair and scalp essence. 
5 days ago
There is a marked difference in the thickness of the granular layer between palmar psoriasis and hand eczema, and this may be helpful in differentiating between the two skin conditions, according to a recent study.
Jan Welch, 6 years ago

Sexually transmitted infections (STIs) are common, with rates of many infections increas­ing over the last two decades.1 Community screening studies in the UK have shown a prevalence of about 10% for chlamydial infection2 and (among women screened in an urban setting) 3% for gonorrhoea.3 In women (Figure 1), these potentially serious infections are often asymptomatic, whereas the presence of symptoms such as vaginal discharge generally indicates a less pathogenic (but still potentially debilitating) infection, with an organism such as Candida. STIs are often multiple, and the finding of one infection should prompt consider­ation of testing for others. Many sexual health services now initially provide screening tests for asymptomatic women, but a more comprehensive assessment—comprising detailed history4 and genital examination5—is usually necessary when symptoms are present.