Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute. 

Antiepileptic drugs, systemic antibacterials up risk of adverse drug reactions

15 Aug 2017

Use of antiepileptic drugs, a history of adverse drug reactions (ADR) and use of meglumine are all risk factors for ADR in paediatric patients, a new cohort study has shown.

In a cohort of 173 children, with 208 admission and 2,167 prescription data, 109 adverse drug events (ADE) were reported in 52 children. Of these, 12.8 percent (n=14) were classified as definite ADR, 47.7 percent (n=52) were probable, 29.4 percent (n=32) were possible and 10.1 percent (n=11) were classified as doubtful.

An analysis of all definite and probable ADRs showed that gastrointestinal disorders were the most common ADR, comprising 28.8 percent (n=19) of all total cases. This was followed by ADR related to systemic antibacterials (22.7 percent) and general anaesthesia (15.2 percent). The overall incidence rates of definite and probable ADRs were 22.1 and 21.9 percent, respectively.

Multivariate analysis showed that a prior history of ADR (hazard ratio [HR], 2.44; 95 percent CI, 1.19 to 5.00; p=0.01) and an administration of meglumine antimonite (HR, 4.98; 1.21 to 20.54; p=0.02) were significant risk factors for ADRs.

Antiepileptic drugs (HR, 3.84; 1.40 to 10.56; p=0.009) and antibacterials for systemic use (HR, 2.75; 1.08 to 6.98; p=0.03) were also significant risk factors for ADR.

Study participants were recruited from a general paediatric ward of a public teaching hospital in Northeastern Brazil. Only those treated for at least 48 hours were included. Those that were not administered drugs during hospital stay were excluded.

The principal outcome of the study was the occurrence of ADRs. The Naranjo and Hartwig algorithms were used to evaluate causality and severity of ADEs, respectively.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacy - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
01 Oct 2013

Heart disease is still New Zealand’s biggest killer, with one Kiwi dying from coronary heart disease every 90 minutes. Pharmacy Today New Zealand looks at how pharmacists can help

Pearl Toh, 11 Oct 2017
Clinical practice is an art guided by good science, and clinical practice guideline (CPG) is meant to guide in integrating the art and science of clinical practice for the long-term benefits of patients, said Dr Abdul Rashid Abdul Rahman, a consultant cardiovascular physician at An-Nur Specialist Hospital in Bangi, Malaysia, during the 13th Asian-Pacific Congress of Hypertension (APCH) held in Singapore.
Dr. James Salisi, 01 Jul 2014

The recent spike in the number of new cases of human immunodeficiency virus (HIV) infection in the Philippines means that clinicians and pharmacists alike may need to increase their awareness and competency in prescribing and monitoring HIV treatment. Although taught in medical and pharmacy schools, the scarcity in exposure to clinical cases before highlights the need to for physicians and pharmacist to review HIV pharmacotherapy in order to cater to the increasing HIV patient population.

01 Sep 2017
Complementary medicines can play an important part in maintaining wellness, preventing deficiencies and optimizing health outcomes, says Dr Lesley Braun PhD, Director of the Blackmores Institute.