Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
11 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 13 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Antibiotic use during first two years of life ups risk of allergies at age five

16 Sep 2017
The increasing shortage of a commonly used antibiotic, Tazocin, has raised concerns on an international scale.

The risks of asthma, atopic dermatitis and allergic rhinitis at 5 years of age are all significantly higher in children who were given antibiotics during the first 2 years of life, a new study from Japan has shown.

Researchers performed a retrospective analysis of data in the Tokyo Children’s Health, Illness and Development Study. Recruitment of 1,701 pregnant women led to the inclusion of 1,550 newborns to 1,504 mothers after exclusion of miscarriages, stillbirths and terminations of pregnancy.

Accomplished questionnaires when the child was 2 and 5 years of age were collected from 1,323 and 1,196 respondents, respectively. Outcomes were allergy symptoms in children at 5 years old such as asthma, rhinitis, wheezing and eczema.

Reponses showed that 48.3 percent of children enrolled in the study were exposed to antibiotics during the first two years of life. The most common antibiotic was cephem, which was used in 21.5 percent. This was followed by macrolide (19.2 percent).

The incidences of bronchitis at two years (p<0.001) and of asthma (p=0.009), atopic dermatitis (p=0.032) and allergic rhinitis (p=0.006) were significantly higher in children who received antibiotics during the first two years of life compared with their nonantibiotic counterparts.

Logistic regression analysis showed that antibiotic use in the first two years of life was significantly associated with elevated risks of asthma (adjusted odds ratio [aOR], 1.72; 95 percent CI, 1.10 to 2.70; p=0.017), atopic dermatitis (aOR, 1.40; 1.01 to 1.94; p=0.044) and rhinitis (aOR, 1.65; 1.05 to 2.58; p=0.03) at 5 years of age.

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Most Read Articles
Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
11 hours ago
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, 13 hours ago
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.