Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.

Altered profile of cytokines, growth factors in AS patients after exercise

19 Mar 2017

Exercise results in an altered pattern of change in circulating growth factors and cytokines, and greater increases in pro-inflammatory cytokines in patients with asymptomatic, moderate-to-severe aortic valve stenosis (AS), a new study shows.

The study included 32 patients (16 males, 17 females) with asymptomatic, moderate-to-severe AS. A separate group of age- and sex-matched individuals was established as a control group. Those with a history of angina, stroke, myocardial infarction, cancer or dizziness, among other complications, were excluded.

Participants performed exercise on a bicycle ergometer and received a continuous stress echocardiographic examination. Plasma levels of interleukin (IL)-10, IL-6, hepatocyte growth factor (HGF), transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF) were measured at rest, at peak exercise, and at 1 hour and 24 hours after exercise.

The stress test was significantly shorter in the AS patients (9.0±1.9 minutes) compared with controls (10.8±2.7 minutes; p=0.008), while the maximum workload was significantly lower (81.3±21.1 W; p=0.002).

The levels of all the markers in both groups increased after exercise (p<0.0001 for all). IL-10 and IL-6 reached significantly higher maximum levels in the AS patients (p<0.005 for all).

In controls, the maximum levels of VEGF, IL-10 and IL-6 were observed during peak exercise. In AS patients, this was observed 1 hour after exercise. On the other hand, maximum TGF-β levels were observed 1 hour after exercise in both groups.

The highest HGF values were observed during peak exercise in AS patients and after the exercise in controls. HGF levels in AS patients were higher during peak exercise and 1 hour after exercise compared with controls (p=0.0001).

After 24 hours, only TGF-β remained elevated relative to resting values in both groups (p=0.0001). No association with workload and heart rate was observed.

The findings suggest that asymptomatic, moderate-to-severe AS patients experience an inflammatory state after exercise.

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Most Read Articles
Pank Jit Sin, 07 Jan 2015

Cardiovascular diseases (CVD) have been the main cause of death in the Malaysian population since 2007. This trend has continued, with the number of people dying from CVD-related causes increasing year on year. 

Elaine Soliven, 11 Oct 2017
Reducing daily salt intake is associated with improved blood pressure (BP) levels in patients with hypertension, according to a study presented at APCH 2017.
Roshini Claire Anthony, 28 Sep 2017

Intensive blood pressure (BP) lowering appears to reduce mortality risk during treatment in individuals with hypertension and moderate-to-advanced chronic kidney disease (CKD), findings from a recent systematic review and meta-analysis show.

21 Sep 2017
The risk of coronary heart disease (CHD), cerebrovascular disease and heart failure is greater among metabolically healthy obese than normal weight metabolically healthy individuals, suggests a recent study. Additionally, even those who are normal weight can have metabolic abnormalities and similar risks for cardiovascular disease (CVD) events.