Most Read Articles
Naomi Rodrig, 2 years ago

Curing leukemia is no longer a dream, especially for leukemia types related to a single known genetic defect, argued Dr. Pia Raanani, Head of Hematology Division at the Rabin Medical Center, Petah Tikva, Israel.

Christina Lau, 2 years ago
Ultrasound screening should be routine for women with mammographically dense breasts, say researchers from Connecticut, the first US state to enact legislation mandating radiologists to inform women with dense breasts of the potential benefit of supplemental screening.
4 years ago

A radiotherapy (RT) technique that delivers much lower doses to the contralateral submandibular gland has been shown to reduce symptoms of dry month in patients with head and neck cancers.

Rajesh Kumar, 4 years ago

Older chemotherapy drugs that are no longer widely used due to their toxicity profiles are finding new uses in cancer treatment, thanks to the development of antibody-drug conjugates.

Albumin-bilirubin grade predicts prognosis in HCC

15 days ago

Albumin-bilirubin (ALBI) grade may predict prognosis in hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE), a new study shows.

The study included 881 HCC patients receiving TACE (median age 68 years; 76 percent male) and showing a median overall survival of 24 months. Hepatitis B (35 percent, n=311) and C (27 percent; n=241), and alcoholism (19 percent; n=162) were the principal causes of HCC.

Of all the tested markers, ALBI grade resulted in the highest homogeneity (43.655) and lowest corrected Akaike information criteria (AICc) value (8,094.296). This was followed by cirrhosis discriminant index (CDS; 35.635 and 8,102.143, respectively) and Child-Turcotte-Pugh score (CTP; 26.861 and 8,111.090, respectively).

Univariate survival analysis showed that alcoholism (hazard ratio [HR], 1.240; 95 percent CI, 1.018 to 1.509; p=0.032), alkaline phosphatase level (HR, 1.678; 1.435 to 1.963; p<0.001), vascular invasion (HR, 2.511; 2.075 to 3.039; p<0.001) and ALBI grades 2 (HR, 1.678; 1.421 to 1.981; p<0.001) and 3 (HR, 1.501; 1.251 to 1.801; p<0.001) were all indicators of poor prognosis.

Multivariate analysis confirmed the significant association of alkaline phosphatase level (HR, 1.362; 1.155 to 1.607; p<0.001), vascular invasion (HR, 1.999; 1.622 to 2.464; p<0.001) and ALBI grade 2 (HR, 1.531; 1.285 to 2.823; p<0.001) to reduced survival.

ALBI grade 3 (HR, 1.525; 0.976 to 2.382l; p=0.064) was only modestly associated with poor survival.

Participants with histologically confirmed HCC were recruited from the Taipei Veterans General Hospitals.

Aside from ALBI, CTP and CDS, the prognostic performances of the following liver reserve markers were also assessed: aspartate transaminase-to-platelet ratio (APRI), fibrosis index based on four factors (FIB-4), Göteborg University Cirrhosis Index (GUCI), model for end-stage liver disease (MELD) and Lok index.

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Most Read Articles
Naomi Rodrig, 2 years ago

Curing leukemia is no longer a dream, especially for leukemia types related to a single known genetic defect, argued Dr. Pia Raanani, Head of Hematology Division at the Rabin Medical Center, Petah Tikva, Israel.

Christina Lau, 2 years ago
Ultrasound screening should be routine for women with mammographically dense breasts, say researchers from Connecticut, the first US state to enact legislation mandating radiologists to inform women with dense breasts of the potential benefit of supplemental screening.
4 years ago

A radiotherapy (RT) technique that delivers much lower doses to the contralateral submandibular gland has been shown to reduce symptoms of dry month in patients with head and neck cancers.

Rajesh Kumar, 4 years ago

Older chemotherapy drugs that are no longer widely used due to their toxicity profiles are finding new uses in cancer treatment, thanks to the development of antibody-drug conjugates.