Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.

Age does not affect treatments, outcomes in hepatocellular carcinoma

19 Sep 2017

Age appears to not significantly impact treatments and outcomes for hepatocellular carcinoma (HCC), a new study reveals. Survival is comparable between older and younger patients, and equally active treatments should be administered to both age groups.

The study included 1,530 adult patients diagnosed with HCC, of which 20.8 percent (n=318) were older than 65 years while the remaining 79.2 percent (n=1,212) were younger. Cigarette and alcohol use and liver cirrhosis were significantly more common in younger patients (p<0.05 for all).

Prior to propensity score matching, there was no significant difference in 30-day mortality between the two groups (p=0.884). In contrast, the 90-day mortality was significantly higher in older than in younger patients (13.2 vs 9.4 percent; p=0.048). The global median 1-, 3- and 5-year survival rates were also worse in older patients.

After propensity score matching for preoperative status, liver function, tumour size and vascular invasion, among others, the statistically significant difference in 90-day mortality was attenuated.

In spite of this, older patients were given curative treatments, such as surgical resection (28.9 vs 24.6 percent) and liver transplant (3.3 vs 0 percent), significantly less than younger patients (p<0.001).

“These findings implied that even with similar host factors and tumour burden, older patients tended to be less aggressively treated than younger patients, which might account for the diminished long-term outcome of elderly patients,” said researchers.

Subsequent multivariable analysis showed that age (hazard ratio [HR], 1.1; 95 percent CI, 0.9 to 1.3; p=0.281) did not significantly affect survival. On the other hand, curative treatments (HR, 0.5; 0.4 to 0.6; p<0.001), locoregional therapies (HR, 0.8; 0.7 to 0.9; p<0.001) and the Eastern Cooperative Oncology Group scores (HR, 1.4; 1.2 to 1.6; p<0.001) were all significantly associated with survival.

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Most Read Articles
Elvira Manzano, 4 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Yesterday
Breast cancer patients have notably different microbiomes in the local breast tissue and urinary tract, a recent study reveals. Particularly, species in the Methylobacterium genus are reduced in the local breast tissue while the urinary tract is enriched in gram-positive bacteria.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
Tristan Manalac, Yesterday
Statin use, particularly in smokers, obese patients and nondiabetics, has a strong and dose-dependent association with decreasing risk of pancreatic ductal adenocarcinoma (PDAC), according to a new study.