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Advanced AMD patients report reduced intake of micronutrients

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There are significant differences in intakes of vitamins C and E, beta-carotene, folate, and vegetables between patients with late-stage age-related macular degeneration (AMD) and healthy controls, according to a recent study, which provides a better understanding of the nutritional intake of patients presenting with advanced AMD.

Compared with controls, patients with late-stage AMD had significantly lower intakes of vitamin E (9.8 vs 7.4 mg/day; p<0.0001), beta-carotene (7,738 vs 6,232 μg/day; p<0.0001), vitamin C (184 vs 161 mg/day; p=0.0002) and folate (602 vs 498.3 μg/day; p<0.0001) but had higher intakes of zinc (11.9 vs 13.0 mg/day; p<0.0001) after multivariable adjustment.

A significantly lower proportion of patients with late-stage AMD met the recommended intake of vegetables than controls (52.9 vs 64.5 percent; p=0.0002).

In this cross-sectional analysis, researchers evaluated dietary behaviours by comparing adjusted mean intakes of micronutrients and major food groups (fruits, vegetables, fish) among patients with late-stage AMD (n=480) and a sample of age‒sex-matched controls with no AMD signs (n=518).

AMD cases (aged >60 years) included those presenting for treatment to a hospital eye clinic in Sydney, Australia, from 2012 to 2015. The healthy controls were obtained from the Blue Mountains Eye Study from 2002 to 2009.

Researchers assessed dietary intake using a semiquantitative food-frequency questionnaire and evaluated AMD lesions from retinal photographs.

“Knowledge of the risk factor profile of patients presenting with late-stage AMD could help identify the most frequent modifiable AMD precursors among people who are referred for treatment,” according to researchers.

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Elvira Manzano, 3 days ago
Bisphosphonates have proven antifracture efficacy and remain to be the cornerstone of osteoporosis treatment. However, a drug holiday is of particular importance with bisphosphonates due to some signals with long-term use of the drug, including rare incidence of atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ), says a leading endocrinologist at AFOS 2017.
Pearl Toh, 13 Oct 2017
Women with higher plasma tryptophan concentrations were less likely to have poor sleep quality during pregnancy, especially among those with anxiety symptoms, according to the GUSTO* study.
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